98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s00134-010-2086-z | DOI Listing |
Rev Cardiovasc Med
August 2025
Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Harlequin syndrome, also known as differential hypoxia (DH) or North-South syndrome, is a serious complication of femoro-femoral venoarterial extracorporeal membrane oxygenation (V-A ECMO). Moreover, Harlequin syndrome is caused by competing flows between the retrograde oxygenated ECMO output and the anterograde ejection of poorly oxygenated blood from the native heart. In the setting of impaired pulmonary gas exchange, the addition of an Impella device (ECPELLA configuration), although beneficial for ventricular unloading and hemodynamic support, may further exacerbate this competition and precipitate DH.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
September 2025
Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Gamal Abdel Nasser, 11835, New Cairo, Egypt.
Licochalcone A (LCA), a natural flavonoid with potent anti-inflammatory properties, has shown promise as a neuroprotective agent. However, its ability to cross the blood-brain barrier (BBB) and exert central effects remains underexplored. In this study, we demonstrate for the first time that LCA enhances cognitive function in a lipopolysaccharide (LPS)-induced neuroinflammatory mouse model and effectively penetrates the BBB.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Pharmacology of Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Gastrodin (GAS), the principal bioactive component derived from Gastrodia elata Bl., has demonstrated efficacy in attenuating methamphetamine (MA) induced conditioned place preference (CPP) in animal models. However, the molecular mechanisms underlying its anti-addictive effects, particularly the role of miRNAs, remain insufficiently understood.
View Article and Find Full Text PDFBiomed Phys Eng Express
September 2025
College of Computer Science and Technology, China University of Petroleum East China - Qingdao Campus, College of Computer Science and Technology, China University of Petroleum (East China), Qingdao 266580, China, Qingdao, Shandong, 266580, CHINA.
Purpose: Cerebrovascular segmentation is crucial for the diagnosis and treatment of cerebrovascular diseases. However, accurately extracting cerebral vessels from Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) remains challenging due to the topological complexity and anatomical variability.
Methods: This paper presents a novel Y-shaped segmentation network with fast Fourier convolution and Mamba, termed F-Mamba-YNet.
Cell Rep
September 2025
Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, MIT, Cambridge, MA 02139, USA; Biology of Adversity Project, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Elect
The neural control of breathing is both dynamic and essential, ensuring life-sustaining gas exchange while protecting the respiratory system from harm. Peripheral neurons innervating the respiratory tract exhibit remarkable diversity, continuously relaying sensory feedback to the brain to regulate breathing, trigger protective reflexes such as coughing and sickness behaviors, and even influence emotional states. Understanding this airway-brain axis is especially critical given the increasing global burden of respiratory diseases, as it holds implications for both human health and broader brain-body interactions.
View Article and Find Full Text PDF