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Article Abstract
Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The congeners prepared are appropriately functionalized to enable access to diverse pleuromutilin analogues.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156455 | PMC |
| http://dx.doi.org/10.1039/c0cc04077k | DOI Listing |
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