Positive reinforcement for viruses.

Chem Biol

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Published: October 2010


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Article Abstract

Virus-cell membrane fusion requires a critical transition from positive to negative membrane curvature. St. Vincent et al. (2010), in PNAS, designed a class of antivirals that targets this transition. These rigid amphipathic fusion inhibitors are active against an array of enveloped viruses.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998992PMC
http://dx.doi.org/10.1016/j.chembiol.2010.10.002DOI Listing

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