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Background: Cannabinoid-containing substances are commonly abused worldwide. Significant toxicity from these substances is uncommon in adults but can result in significant symptoms in children; these symptoms are usually short-lived.
Objectives: To report a case of prolonged mental status alteration of more than 2 days in a child who ingested hashish.
Case Report: A 14-month-old child presented comatose to a pediatric emergency department after ingestion of hashish; she did not regain consciousness for more than 48 h. Quantitative testing of the child's urine for a tetrahydrocannabinol metabolite revealed a markedly elevated level, the decline of which coincided with the child's clinical improvement.
Conclusions: Significant ingestion of cannabinoid-containing substances is capable of causing prolonged symptoms (including coma) in children.
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http://dx.doi.org/10.1016/j.jemermed.2010.05.032 | DOI Listing |
Pharmacol Biochem Behav
September 2025
Graduate School in Neuroscience, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: fabriciomoreira@icb
Conditioned fear is a response to contexts or cues previously paired with aversive stimuli. Substances from the herb Cannabis sativa (phytocannabinoids), such as cannabidiol (CBD), prevent fear responses and hold potential as new treatments for certain psychiatric disorders, such as post-traumatic stress disorder. The phytocannabinoid cannabigerol (CBG), similarly to CBD, lacks psychotomimetic effects and targets multiple receptors involved in fear-related pathways.
View Article and Find Full Text PDFBehav Pharmacol
February 2025
Department of Pharmacology, Biological Sciences Sector, Federal University of Paraná.
Opioid use disorder is a public health problem that includes symptoms such as withdrawal syndrome and opioid-induced hyperalgesia. Currently, drugs to treat side effects of opioids also have undesirable effects, which lead to limitations. This study investigated the effect of a treatment with cannabidiol in morphine-induced hyperalgesia and withdrawal behavior in morphine-dependent rats.
View Article and Find Full Text PDFCannabis Cannabinoid Res
July 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
To evaluate the label accuracy and content of various hemp-derived cannabidiol (CBD) products (cannabinoid products with ≤0.3% Δ-tetrahydrocannabinol [THC]), as well as evaluate advertised claims on product labels. Hemp haircare, cosmetics, and food/drink products that were advertised to contain CBD were purchased from retail stores in the Baltimore, Maryland area (purchased in July 2020) and online (purchased in August 2020).
View Article and Find Full Text PDFMolecules
December 2023
Department of Food Chemistry and Biocatalysis, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Hemp is used as a source of fiber, oil and bioactive substances including volatile and cannabinoid-containing substances. This paper presents, for the first time, results on the evaluation of drying methods (convective, vacuum-microwave and combined convective pre-drying and vacuum-microwave finishing drying) of hemp leaves on the qualitative and quantitative changes in secondary metabolites, including essential oils, cannabinoids and sterols. A ranking and descriptive test of hemp leaves was also performed.
View Article and Find Full Text PDFBraz J Psychiatry
November 2021
Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Objective: To assess the efficacy of cannabidiol (CBD) in the management of crack-cocaine craving and the treatment of frequent withdrawal symptoms.
Methods: Thirty-one men with a diagnosis of crack-cocaine dependence were enrolled in a randomized, double-blind, placebo-controlled trial. We applied neuropsychological tests and assessed craving intensity, anxiety and depression symptoms, and substance use patterns at baseline and at the end of the trial.