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Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration
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http://dx.doi.org/10.1002/mds.23100 DOI Listing Publication Analysis
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Brain Stimul
September 2025
Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address:
Background: Precisely timed brain stimulation, such as phase-locked deep brain stimulation (PLDBS), offers a promising approach to modulating dysfunctional neural networks by enhancing or suppressing specific oscillations. However, its clinical application has been hindered by the lack of user-friendly systems and the challenge of real-time phase estimation amid stimulation artifacts.
Material And Method: In this work, we developed a clinically translatable PLDBS framework that enables real-time, cycle-by-cycle stimulation using standard amplifiers and a computer-in-the-loop system.
Integr Med Res
March 2026
National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, Faculty of Health Sciences, The Arctic University of Norway UiT, Tromsø, Norway.
Background: Athroplastic surgery often results in acute post-operative pain, hindering rehabilitation compliance. To improve pain management and functional recovery, guided and motor imagery (GMI) exercises were introduced in hip and knee arthroplasty.
Methods: A pragmatic prospective mixed-methods implementation evaluation was conducted at the orthopaedic department of Schakelring, the Netherlands.
Aging Clin Exp Res
September 2025
Division of Rehabilitation Sciences, Department of Health Sciences, Medical School, Nagoya City University, Nagoya, Japan.
Objective: This study aimed to investigate the relationship between ankle joint function and walking performance in older adults by assessing qualitative ankle functions through torque fluctuation analysis and tibialis anterior (TA) intramuscular coherence during isometric dorsiflexion.
Methods: Thirty-eight community-dwelling older adults participated in this study. Ankle torque fluctuations and intramuscular coherence were evaluated during a dorsiflexion task at 30% of maximum voluntary torque (MVT).
Br J Occup Ther
September 2025
Sir Charles Gairdner Osborne Park Health Care Group, Occupational Therapy, Perth, WA, Australia.
Introduction: Upper limb dysfunction is common in people with Parkinson's. This study aimed to pilot and establish the initial psychometric properties of the timed upper limb assessment (TULA), a 10-item timed functional upper limb assessment tool.
Method: A prospective observational study was conducted with 381 participants (202 with Parkinson's, 179 controls).
Neurol Res Pract
September 2025
Department of Neurology, Philipps-University Marburg, Biegenstraße 10, 35032, Marburg, Germany.
Background: Parkinson's disease (PD) multimodal complex treatment (PD-MCT) is an inpatient therapeutic programme specifically designed for patients exhibiting parkinsonian symptoms. Established in Germany, this comprehensive approach addresses the multifaceted challenges associated with the management of PD, particularly in advanced stages or when complications such as motor fluctuations, dyskinesia, or non-motor symptoms become pronounced. The programme integrates pharmacological optimization, physiotherapy, occupational therapy, speech therapy, and psychological support, among other complementary therapies, to enhance patient outcomes holistically.
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