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Article Abstract
Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.
Case Presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.
Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874792 | PMC |
| http://dx.doi.org/10.1186/1471-2377-10-30 | DOI Listing |
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