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Objectives: The objectives of the study were to describe the clinical presentation, diagnostic process, surgical treatment, and outcome of patients with spontaneous dural defect of temporal bone and to explore the possible contribution of idiopathic intracranial hypertension.
Methods: Medical records of consecutive patients with spontaneous defects of the temporal bone were reviewed. Clinical presentation, diagnostic process, exploration of benign intracranial hypertension, surgical management, and outcome of patients are presented.
Results: Six of the 12 patients presenting with spontaneous cerebrospinal fluid otorrhea were women. Ages ranged from 38 to 76 years. Seven patients presented with meningitis. The location and the extent of the occurring defect were detected by computed tomography in all cases. Radiologic signs of empty sella syndrome, indicator of benign intracranial hypertension, were revealed in 3 cases using magnetic resonance imaging. Six tegmen defects were repaired using a middle fossa approach without recurrence. Four patients received the combined approach. All patients had complete resolution of the cerebrospinal fluid leak, although 2 cases developed adverse effects attributable to surgical procedure.
Conclusion: The diagnosis of spontaneous cerebrospinal fluid otorrhea requires clinical suspicion in the setting of meningitis and persistent serous otitis media. High-resolution computed tomography can confirm the diagnosis. The authors' findings advocate the multilayered closure technique through a middle fossa approach.
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http://dx.doi.org/10.1016/j.amjoto.2009.12.003 | DOI Listing |
J Anat
September 2025
Department of Biological Sciences (Anthropology), Graduate School of Science, The University of Tokyo, Tokyo, Japan.
The uniqueness of human brain growth and development has been considered promising for its contribution to understanding the origins of the unique human cognitive abilities. Compared with that of chimpanzees, the human endocranium undergoes several characteristic shape changes immediately after birth, which has been termed "endocranial globularization." However, how the brain structures and surrounding neurocranium interact with each other during early development in the context of brain-neurocranium integration remains to be investigated.
View Article and Find Full Text PDFDev Cell
September 2025
Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:
Lineage specification requires accurate interpretation of multiple signaling cues. However, how combinatorial signaling histories influence fate outcomes remains unclear. We combined single-cell transcriptomics, live-cell imaging, and mathematical modeling to explore how activin and bone morphogenetic protein 4 (BMP4) guide fate specification during human gastrulation.
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
Department of Anatomy, UP University of Medical Sciences, Saifai, Etawah, UP, India.
Foramina in the orbit are well described in the literature. But the author of the present study observed an unusual foramen in the frontal process of the zygomatic bone, not reported so far, as far as the author knows. This foramen was observed in 2 skulls, in one skull bilaterally and in another skull unilaterally on the left side.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Research, Collections and Conservation, Environmental Archaeology and Materials Science, National Museum of Denmark, Kongens Lyngby, Denmark.
During the Late Bronze Age (ca. 11th-8th century BCE), far-reaching and extensive trade and exchange networks linked communities across Europe. The area around Seddin in north-western Brandenburg, Germany, has long been considered as at the core of one such networks.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Department of Orthopaedic and Reconstructive Surgery/Pediatric Orthopaedics, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Distraction osteogenesis (DO) is an endogenous bone tissue engineering technique that harnesses the regenerative potential of bone and has been widely applied in limb lengthening, bone defect repair, and craniofacial reconstruction. The DO procedure consists of three distinct phases: the latency phase, the distraction phase, and the consolidation phase, each characterized by unique biological processes. In recent years, increasing attention has been directed toward the role of the immune system during DO.
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