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We tested the immunoreactivity of KCC2 using KCC2 antibody in the developmental mouse medulla. Age-dependent changes in immunoreactivity were remarkable in the hypoglossal nucleus, and interestingly, the immunoreactivity in the hypoglossal nucleus relative to the dorsal vagal nucleus at P0 appeared to be higher than that of P7. Thus Cl(-) homeostasis in the hypoglossal nucleus might be differentially regulated in the developmental stage.
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http://dx.doi.org/10.1007/978-1-4419-5692-7_6 | DOI Listing |
Zhen Ci Yan Jiu
August 2025
Clinical School of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Objectives: To investigate the mechanisms by which the hypoglossal nucleus (12N) modulates swallowing-related activities and mediates the therapeutic effects of electroacupuncture (EA) at "Lianquan" (CV23) in alleviating post-stroke dysphagia (PSD).
Methods: Tracer viruses were used to investigate the brain regions that directly project to CV23. C57BL/6J mice were divided into 7 groups:control, model, model+EA, normal+12N inhibition control, normal+12N inhibition, model+EA+12N inhibition control, and model+EA+12N inhibition groups (7 mice/group).
J Comp Neurol
July 2025
School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Social behaviors in the African wild dog involve a range of complex movements, including biting, pushing, embracing, mounting, face and muzzle licking, paw placement, play fighting, and wrestling. In this study, we employ a range of architectural and immunohistochemical stains to provide a qualitative description of the motor system in the brain of one representative individual of the African wild dog. The appearance of the motor system in the African wild dog does not differ substantively to that reported in other carnivores and is neurochemically like that of the domestic dog; however, one significant difference was detected: the presence of a distinct fascicle of protoplasmic commissural dendrites at the rostral pole of the hypoglossal nucleus.
View Article and Find Full Text PDFNeuropathology
August 2025
Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
We present the case of an 81-year-old man diagnosed with probable amyotrophic lateral sclerosis (ALS) based on the Updated Awaji criteria. The patient exhibited progressive motor neuron degeneration with muscle weakness, atrophy, and fasciculations primarily in the right lower limb and later extending to the right upper limb. Three months after being referred to a home care clinic, he collapsed in front of his family members and died.
View Article and Find Full Text PDFJ Virol
November 2024
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.