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Facial appearance is largely determined by the morphology of the underlying skeleton. Hydroxyapatite is one of several materials available to enhance projection of the facial skeleton. This study evaluated the long-term maintenance of augmented bony projection when porous hydroxyapatite granules are used on the facial skeleton. Ten female patients aged 28-58 years were studied following aesthetic augmentation of the facial skeleton at 24 sites using porous hydroxyapatite granules. Postoperative CT scans at 3 months served as the baseline measurement and compared with scans taken at 1 and 2 years, with the thickness of the hydroxyapatite measured in axial and coronal planes. Thickness of original bone plus overlay of hydroxyapatite, thickness of the overlying soft tissue, and the overall projection (bone plus soft tissue) were recorded. It was found that 99.7% of the hydroxyapatite was maintained at 2 years, with no statistical difference (t test) from the baseline measurement. The overall projection (bony and soft tissue) was maintained as there was no evidence of native bone resorption or soft tissue atrophy. Radiographic results confirmed that the use of porous hydroxyapatite granules for enhancement of the facial skeleton is not only a predictable procedure, but maintains full bony projection at 2 years.
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http://dx.doi.org/10.1007/s00266-010-9473-2 | DOI Listing |
Dent Mater J
September 2025
Dental Material, Sciences and Technology Department, Faculty of Dental Medicine, Universitas Airlangga.
This study was aimed to analyze the structural and chemical properties of scaffolds prepared using the bovine rib bone. The bovine rib bone was extracted and processed by water jet washing, hydrogen peroxide treatment, and freeze drying to obtain porous scaffolds. Scanning electron microscopy analysis revealed that the scaffold was composed of interconnected trabeculae networks with an average pore diameter of 223 µm.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Marine College, Shandong University, Weihai 264209, China. Electronic address:
The current method of using scaffold materials to repair bone defects still faces limitations in achieving biomimetic mineralization and endogenous bone tissue regeneration. Therefore, we have developed a novel ALN doped chitosan/hydroxyapatite (CS/ALN/nHAP) micro nano hybrid scaffold based on in situ tissue engineering principles. The addition of alendronate (ALN) increases nucleation sites, enhances biomimetic mineralization of nHAP in situ, and promotes the aggregation of endogenous stem cells.
View Article and Find Full Text PDFActa Biomater
August 2025
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.
Regenerative bioceramics for bone repair require an optimal balance of mechanical properties and osteogenic activity. Achieving this dual enhancement remains a significant challenge, particularly regarding the intrinsic properties of the ceramic. This study introduces a one-step solid-phase reaction strategy to generate new phase and nanostructure to enhance the performance of hydroxyapatite (HA) ceramic for bone repair.
View Article and Find Full Text PDFJ Dent Res
September 2025
Université Paris-Saclay, CentraleSupélec, ENS Paris-Saclay, CNRS, LMPS - Laboratoire de Mécanique Paris-Saclay, Gif-sur-Yvette, France.
Like bone, dentin exhibits a complex multiscale hierarchical structure. Dentin microstructure has been widely studied at the microscale, using direct 2-dimensional observation techniques such as optical and scanning electron microscopy. Its porous network microstructure has been recently revealed in 3 dimensions using confocal laser scanning microscopy.
View Article and Find Full Text PDFActa Biomater
August 2025
Department for Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany. Electronic address:
Calcium phosphate cements (CPCs) are widely used as medical devices for treating bone defects due to their high biocompatibility and ease of clinical application. Their porous structure and low setting temperature make them suitable as drug delivery systems, enabling high local drug concentrations while minimizing systemic side effects. However, successful application requires predictable drug release and a thorough understanding of drug-cement interactions.
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