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The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
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http://dx.doi.org/10.1039/b909551a | DOI Listing |
Semin Ultrasound CT MR
September 2025
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:
Fetal magnetic resonance imaging (MRI) is a safe method of in-utero evaluation of fetal anomalies and a valuable adjunct to prenatal ultrasound. The utilization of rapid sequences reduces the impact of fetal motion and allows for high contrast resolution of fetal structures. A thorough understanding of fetal anatomy and a systematic approach to MRI interpretation are essential for accurate diagnosis of fetal head and neck anomalies.
View Article and Find Full Text PDFJ Control Release
September 2025
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China; Dongguan Liaobu Hospital, Dongguan 523400, Guangdong, China. Electronic address:
Fluorine-19 magnetic resonance imaging (F MRI) offers distinct advantages, including background-free signal detection, quantitative analysis, and deep tissue penetration. However, its application is currently limited by challenges associated with existing F MRI contrast agents, such as short transverse relaxation times (T), limited imaging sensitivity, and suboptimal biocompatibility. To overcome these limitations, a glutathione (GSH)-responsive triblock copolymer (PB7), featuring self-immolative characteristics, has been developed.
View Article and Find Full Text PDFBiochem Biophys Res Commun
August 2025
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA. Electronic address:
Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as powerful tools in nanomedicine owing to their heavy-metal-free composition, distinct magnetic properties, biocompatibility, and customizable surface chemistry. While traditionally employed as T-weighted MRI contrast agents, recent innovations have enabled the development of ultra-small SPIONs-such as exceedingly small SPIONs (ES-SPIONs) and single-nanometer iron oxide nanoparticles (SNIOs)-that offer T-weighted MRI capabilities, which are favored by radiologists for their superior anatomical clarity. This review highlights the synthesis of monodisperse SPIONs via thermal decomposition and controlled oxidation, as well as their functionalization with zwitterionic dopamine sulfonate (ZDS) ligands, which confer colloidal stability, minimal protein adsorption, and efficient renal clearance.
View Article and Find Full Text PDFEur J Radiol
September 2025
Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071000, China. Electronic address:
Purpose: The present study aimed to develop a noninvasive predictive framework that integrates clinical data, conventional radiomics, habitat imaging, and deep learning for the preoperative stratification of MGMT gene promoter methylation in glioma.
Materials And Methods: This retrospective study included 410 patients from the University of California, San Francisco, USA, and 102 patients from our hospital. Seven models were constructed using preoperative contrast-enhanced T1-weighted MRI with gadobenate dimeglumine as the contrast agent.
IEEE Trans Med Imaging
September 2025
Intravoxel Incoherent Motion (IVIM) MRI is a contrast-agent-free microvascular imaging method finding increasing use in biomedicine. However, there is uncertainty in the ability of IVIM-MRI to quantify tissue microvasculature given MRI's limited spatial resolution (mm scale). Nine NRG mice were subcutaneously inoculated with human pancreatic cancer BxPC-3 cells transfected with DsRed, and MR-compatible plastic window chambers were surgically installed in the dorsal skinfold.
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