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A 62-year-old man with transitional-cell carcinoma of the bladder had undergone transurethral resection and adjuvant treatment with several intravesical instillations of bacillus Calmette-Guerin 10 months earlier. The patient was referred for F-18 FDG PET/CT after detection of mediastinal lymphadenopathy on follow-up CT. Beside moderately increased FDG uptake in bilateral hilar and bronchopulmonary lymph nodes, focally intense FDG uptake was detected in the right lobe of the prostate. Histopathologic evaluation revealed granulomatous prostatitis which is a recognized rare complication of intravesical instillation of BCG during the treatment of superficial bladder cancer.
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http://dx.doi.org/10.1097/RLU.0b013e3181b06c89 | DOI Listing |
Int J Mol Sci
July 2025
Periodic Fever and Rare Diseases Research Centre, Catholic University of Sacred Heart, 00168 Rome, Italy.
() is a commensal bacterium of the skin microbiota that can transform itself into a pathogen depending on the peculiar susceptibility of the host: it is the sole microorganism so far to be found in the specific organ lesions of sarcoidosis, and -induced activation of T-helper-type-1 cell responses is generally higher in patients with sarcoidosis than in healthy subjects. This bacterium acts as an opportunistic agent in several inflammatory conditions other than sarcoidosis, such as prostate cancer and prosthetic joint infections. Both innate and adaptive immunity systems are involved in the pathogenesis of -mediated sarcoid lesions, and a seminal role is played by host toll-like receptor (TLR)-2, TLR-4, TLR-6, NOD-like receptors, and mononuclear cell cytoplasmic receptors.
View Article and Find Full Text PDFClin Nucl Med
July 2025
Department of Nuclear Medicine, West China Hospital of Sichuan University, Sichuan, People's Republic of China.
Kimura disease (KD) is a rare, benign chronic inflammatory disorder characterized by granulomatous inflammation with eosinophilic infiltration. We herein describe 68Ga-PSMA PET/CT findings of KD in the left axilla in a case of prostate adenocarcinoma. This case indicates that KD may cause false-positive results when using PSMA PET in the staging of prostate cancer.
View Article and Find Full Text PDFInt J Mol Sci
May 2025
Department of Medical Chemistry and Biochemistry, MU-Sofia, 1431 Sofia, Bulgaria.
We aim to investigate the role of the family () in the onset and progression of prostate cancer (PCa) and to profile the local PCa immunological status. A total of 116 "tru-cut" biopsies (58 PCa and 58 benign prostatic hyperplasia [BPH]) and 49 formalin-fixed paraffin-embedded (FFPE) instances of PCa were analysed using real-time qPCR and histological examination. Infection with CMV, EBV, HHV6, and HHV7 was detected in 11.
View Article and Find Full Text PDFDiagn Interv Radiol
May 2025
Icahn School of Medicine at Mount Sinai, Department of Diagnostic, Molecular and Interventional Radiology, New York, USA.
Purpose: To investigate the multiparametric magnetic resonance imaging (mpMRI) characteristics of granulomatous prostatitis (GP) and share our experience with 31 pathologically confirmed GP lesions in 19 patients.
Methods: This two-center retrospective study reviewed the pathological and imaging data of 856 patients who underwent prostate biopsy between January 2012 and April 2024. Of these, 19 patients with available prebiopsy mpMRI and a pathologically confirmed diagnosis of GP were included.
Ocul Immunol Inflamm
September 2025
Department of Uvea and Ocular Inflammation, Prabha Eye Clinic and Research Centre and Vittala International Institute of Ophthalmology, Bengaluru, India.
Purpose: We report a rare case of cancer associated retinopathy with multimodal imaging, as an initial presentation of biopsy proven prostate acinar adenocarcinoma and a lung nodule with granulomatous inflammation.
Materials & Methods: Retrospective case report with review of literature.
Results: A 71-year-old man with decrease in vision in left eye was diagnosed to have outer retinal involvement (OU) on autofluorescence and spectral OCT.