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We present descriptions of two human Mycobacterium microti infections: one of a patient with pulmonary disease and one of a patient with osteomyelitis of the hip. Both patients had acid-fast bacilli and a positive Mycobacterium tuberculosis complex PCR from clinical specimens, but mycobacterial cultures remained negative. The microbiological diagnosis was established by molecular methods.
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http://dx.doi.org/10.1128/JCM.00772-09 | DOI Listing |
Front Med (Lausanne)
August 2025
Department of Dermatology, Venereology and Leprosy, Datta Meghe Institute of Higher Education and Research, Wardha, India.
Leprosy, induced by , and in some cases, , remains an important public health issue in endemic regions despite ongoing elimination efforts. Histoid Hansen's disease, a variant of lepromatous leprosy, is characterised by shiny, well-defined nodules and a heavy acid-fast bacillary load. We present a case of a 50-year-old male agricultural worker from rural central India presenting during a community health camp with multiple cutaneous nodules clinically suggestive of histoid leprosy.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Pulmonology, Institute of Pneumology, Bucharest, Romania.
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology, characterized by the formation of non-caseating granulomas in affected tissues and organs. In over half of the cases, the disease undergoes spontaneous remission. In contrast, tuberculosis (TB) is an infectious disease caused by , which, if left untreated, can be fatal.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontei
Background: Mycobacterium simiae is a slow-growing environmental nontuberculous mycobacterium (NTM), commonly isolated from soil and water. M. simiae is not known to transmit zoonotically or via human-to-human contact; infection is presumed to occur through direct environmental exposure.
View Article and Find Full Text PDFMonaldi Arch Chest Dis
September 2025
Department of Community Medicine, K S Hegde Medical College, Mangaluru, Karnataka.
Fiber-optic bronchoscopy (FOB) plays a crucial role in the diagnosis and management of various pulmonary diseases by offering direct visualization of the airways and enabling targeted sampling for microbiological and histopathological evaluation. This study aimed to assess the clinical, radiological, microbiological, and histopathological profiles of patients undergoing FOB. A retrospective analysis of 103 participants who underwent the procedure over one year was conducted.
View Article and Find Full Text PDFVet Pathol
September 2025
Cornell University, Ithaca, NY.
Mycobacteria ( family) comprise five genera (, , , , and ), which include relevant animal and human pathogens. Histology is a rapid method for preemptively diagnosing mycobacteriosis, contributing to surveillance, control, and eradication. A constraint on histology is the limited sensitivity and specificity of acid-fast stains, as the number of detectable bacilli in formalin-fixed paraffin-embedded (FFPE) tissue varies and other microorganisms are acid-fast positive.
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