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Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. False-positive results were found for patients with malaria or past dengue infections. Three ELISAs showing strong agreement with reference ELISAs will be included in the World Health Organization Bulk Procurement Scheme.
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http://dx.doi.org/10.3201/eid1503.080923 | DOI Listing |
ACS Omega
September 2025
Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Dengue virus remains a significant global health threat, imposing a substantial disease burden on nearly half of the world's population. The urgent need for effective antiviral therapeutics, including therapeutic peptides targeting the Dengue virus, is critical in the current healthcare landscape. However, the availability of anti-Dengue peptides (ADPs) data remains limited in existing data sets, posing a challenge for computational modeling and discovery.
View Article and Find Full Text PDFPLoS One
August 2025
Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India.
Background: Pre-existing dengue antibodies could potentially exacerbate disease severity through antibody-dependent enhancement (ADE). Current serological assays focus on measuring neutralizing antibodies for vaccine evaluation, but don't measure sub-neutralizing antibodies that enhance infection via Fcγ receptors. Consensus on a standardized system for measuring dengue virus ADE remains elusive.
View Article and Find Full Text PDFFront Immunol
August 2025
Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Introduction: Dengue virus (DENV), a mosquito-borne flavivirus, leads to over 390 million annual infections worldwide, and there are no approved antivirals so far. Rhododendron mariae (RM), a traditional Chinese herb abundant in flavonoids and triterpenoids, is used to treat respiratory disorders, yet its antiviral potential has been little explored. This study sought to assess the activity and mechanism of RM-1, an extract from RM, against DENV.
View Article and Find Full Text PDFJ Med Virol
August 2025
Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
India, being dengue (DENV) endemic country, faces recurrent outbreaks. Favorable environmental conditions for dengue in eastern India also enhanced patient mortality during 2019-2024. The current study was performed to understand the effect of DENV secondary infection, hematological and biochemical parameters, serotypic shift, and viral load on disease severity.
View Article and Find Full Text PDFChem Biodivers
August 2025
Department of Pharmaceutical Quality Control, University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Three undescribed compounds, including compounds 1 and 2 with a bicyclo[3.2.1]octane skeleton, along with a coumarin derivative (compound 3) and seven known compounds (4-10), were isolated from the heartwood of Mansonia gagei.
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