98%
921
2 minutes
20
Tetanus is endemic in many developing countries. Although propofol has been proposed for sedation in tetanus, the routine use of this drug has not been clearly documented in published reports. A few studies have reported its beneficial effects but no randomized studies are available. We describe the case of a five-year-old boy who presented with severe tetanus in East Africa. The antispastic therapy consisted of benzodiazepine infusion with the addition of titrated boluses of propofol. Intubation and mechanical ventilation were avoided.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1258/td.2008.080236 | DOI Listing |
J Anesth Analg Crit Care
August 2025
Department of Anesthesiology, Yas Clinic Khalifa City/Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates.
Background: Spinal cord stimulation is a validated approach for managing chronic pain syndromes. The stimulator placement typically requires sedation, and an awake phase is needed to ensure optimal lead positioning. We describe a novel multimodal sedation approach using target-controlled infusions of propofol, remifentanil, and dexmedetomidine, combined with boluses of ketamine, guided by electroencephalography and nociception-antinociception balance monitoring.
View Article and Find Full Text PDFCureus
July 2025
Anesthesia, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
This report describes a case of a 15-year-old pediatric patient with mitochondrial depletion syndrome, associated with hypertrophic cardiomyopathy, who underwent scoliosis correction surgery under neurophysiological monitoring. As propofol is mitochondrion-toxic, the anesthetic approach was modified to involve dexmedetomidine infusion combined with boluses of midazolam and ketamine. The patient was hemodynamically stable during surgery with effective neuromonitoring readings, and the surgery was concluded uneventfully.
View Article and Find Full Text PDFCureus
August 2025
Anesthesiology, Mount Sinai Hospital, New York City, USA.
Redo valve-in-valve transcatheter aortic valve replacement (TAVR) confronts anesthesiologists with compounded hemodynamic and neurologic risk. We managed an 85-year-old male with severe mixed prosthetic aortic dysfunction whose pre-procedural transthoracic echocardiogram showed a peak velocity of 3.7 m/s⁻¹, a mean gradient of 24 mm Hg, an effective orifice area of 0.
View Article and Find Full Text PDFNeurol Int
May 2025
Department of Neurology, Lamezia Terme Hospital, 88046 Catanzaro, Italy.
Status epilepticus (SE) is a neurological emergency. Current evidence dictates a step-by-step approach with a first line of therapy consisting of benzodiazepines (BDZs). In many situations, the currently approved approach does not terminate a BDZ-resistant SE.
View Article and Find Full Text PDFIntensive Crit Care Nurs
August 2025
Departments of Pharmacy and Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, Westminster Bridge Road, London, SE1 7EH, UK; Institute of Pharmaceutical Sciences, School of Cancer & Pharmaceutical Sciences, Centre for Human & Applied Physiological Sciences (CHAPS), School of Bas
Background: Diurnal variation of analgosedation may worsen patient outcomes. However, there is no data reporting diurnal variation in patients receiving extracorporeal membrane oxygenation (ECMO).
Objectives: To compare diurnal variation of analgosedation doses in mechanically ventilated adult patients and those receiving ECMO.