Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: We investigated the effects of experimentally induced hyperthyroidism on seminal vesicle pressure measurements and bulbospongiosus muscle contractile activity in a para-chloroamphetamine (Sigma-Aldrich) induced ejaculation model in rats.
Materials And Methods: Male Wistar rats were used in the study. Daily injection of 25 microg/100 gm body weight L-thyroxine (T4, Sigma-Aldrich) for 14 days was performed in 14 rats to induce hyperthyroidism. Seven L-thyroxine injected rats were in the hyperthyroid group. The remaining 7 rats (recovery group) underwent operation after a 28-day washout period to determine spontaneous recovery from hyperthyroidism. At each operation seminal vesicle catheterization was done to measure intraluminal pressure and bulbospongiosus muscle dissection was performed for electromyography. After intraperitoneal administration of 5 mg/kg para-chloroamphetamine physiological parameters related to the ejaculatory process were measured.
Results: The interval between para-chloroamphetamine administration and first ejaculation was significantly decreased in the hyperthyroid rat group compared with that in the control group (mean +/- SD 202.8 +/- 22.3 vs 465.4 +/- 104.6 seconds, p = 0.001). Seminal vesicle phasic contraction frequency was significantly higher than control group values in hyperthyroid rats (for 30 minutes 32.3 +/- 13.9, p = 0.047). The mean AUC of bulbospongiosus muscle electromyography activity was also significantly increased in this group (11.1 +/- 4.1 V per second x 10(-4), p = 0.0001). All parameters in recovery and control group rats were not significantly differed from each other.
Conclusions: Hyperthyroidism leads to enhanced seminal vesicle contraction frequency and bulbospongiosus muscle contractile activity in rats. Hyperthyroidism affects the emission and expulsion phases of ejaculation in reversible fashion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.juro.2008.10.061 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
South Asian Cocktail Disrupts Testicular Integrity, Steroidogenesis and Spermatogenesis by Targeting Steroidogenic Enzymes and Germ Cells via an Oxidative Stress Mediated Pathway.
Food Chem Toxicol
September 2025
Department of Human Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Globally, the South Asian Cocktail (SAC), a substance of abuse, is becoming popular. The effects of SAC on male fertility are unknown; however, its component pharmaceuticals, such as codeine, rohypnol, and promethazine, have been linked to male infertility. Thus, this study assessed SAC's influence and putative mechanisms on male fertility among SAC consumers.
View Article and Find Full Text PDFFamily History of Prostate, Breast, Ovarian, and/or Pancreatic Cancer and Associations with Grade Reclassification in a Large Prostate Cancer Active Surveillance Cohort.
Eur Urol Oncol
September 2025
The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Background And Objective: The effect of family history (FH) on prostate cancer active surveillance outcomes is unknown. Our objective is to evaluate FH of prostate, breast, ovarian, and/or pancreatic cancer in a large prospective active surveillance cohort.
Methods: Patients with recorded FH data (N = 1421) were selected.
Extracellular vesicles: key mediators in embryo production.
Front Vet Sci
August 2025
Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Nano-sized extracellular vesicles (EVs) possess a lipid bilayer and are secreted from cells into their surrounding environment. The transport of multiple biomolecules, including DNA together with RNA, microRNAs (miRNAs), lipids, proteins, and metabolites, happens through biofluids via EVs for intercellular communication. Extracellular vesicles play crucial roles during the embryo production (IVEP) process.
View Article and Find Full Text PDFIncidental Cystadenomas of the Seminal Vesicle: An Institutional Series.
Int J Surg Pathol
September 2025
Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Cystadenoma of the seminal vesicle is a benign epithelial tumor composed of variably sized cysts, lined by bland epithelial cells, and surrounded by fibromuscular stroma. Considered rare and mostly described in case reports, affected patients are frequently described as presenting with obstructive urinary symptoms due to mass effect. Nonetheless, anecdotally, we have seen these tumors present more frequently as smaller, incidental lesions.
View Article and Find Full Text PDFSeminal vesicle abscess with orchitis and emphysematous cystitis following traumatic urethral injury from accidental urinary catheter dislodgement.
Infect Dis Health
September 2025
Department of Infectious Diseases and Laboratory Medicine, Kanazawa University, Kanazawa 920-8641, Ishikawa, Japan.
Background: Indwelling urinary catheters are widely used in hospitalized patients but can be inadvertently dislodged due to trauma, leading to complications such as catheter-associated urinary tract infections and urological injuries.
Case Report: An 87-year-old man developed a seminal vesicle abscess (SVA) caused by Pseudomonas aeruginosa following urethral injury due to accidental urinary catheter dislodgement. The patient presented with hematuria and penile bleeding following dislodgement of the urinary catheter, and subsequently developed fever and a urinary tract infection.