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Subcutaneous Panniculitis-Like T-Cell Lymphoma in Children: Two Case Reports.
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Doctoral School, Medical University of Lublin, Lublin, Poland.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma derived from cytotoxic αβ T cells, clinically and histopathologically resembling inflammatory diseases of adipose tissue, particularly lupus panniculitis. It accounts for <1% of all non-Hodgkin's lymphomas, with approximately 20% of cases occurring in children. The main aim of this paper was to present two pediatric cases of SPTCL, highlighting the diagnostic challenges involved.
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Department of Pediatrics, Pusan National University School of Medicine, Pusan National University Children's Hospital, Yangsan 50612, Republic of Korea.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a very rare subtype of cutaneous T-cell lymphoma. It is characterized by the neoplastic infiltration of subcutaneous adipose tissue. Its clinical presentation, including subcutaneous nodules, fever, and systemic symptoms, often mimics inflammatory panniculitis, making diagnosis difficult.
View Article and Find Full Text PDFAutologous fat grafting to correct severe facial lipoatrophy secondary to subcutaneous panniculitis-like T-cell lymphoma: A case report with 2-year follow-up.
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Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College, China.
Subcutaneous panniculitis-like T-cell lymphoma is a rare type of T-cell lymphoma that causes multiple painless subcutaneous nodules over the body. Patients with subcutaneous panniculitis-like T-cell lymphoma may develop facial lipoatrophy that causes disfigurement. We report the case of a 53-year-old female patient with subcutaneous panniculitis-like T-cell lymphoma and severe facial lipoatrophy who underwent three sessions of autologous fat grafting.
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The association between autoimmune diseases and lymphoproliferative disorders is well established. It is also recognized that the skin and deep subcutaneous tissue can be affected by lymphocytic infiltrates in autoimmune diseases, a hallmark of lupus erythematosus profundus or lupus panniculitis (LP). To present an unusual lymphoproliferative disorder in a patient with undifferentiated connective tissue disease (UCTD).
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July 2025
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A young pregnant woman in her 20s presented with a 2 month history of high-grade intermittent fever. She exhibited multiple painful nodules scattered across her body for 2 months, initially small but progressively increasing in size. Initially diagnosed with Sweet syndrome, a skin biopsy revealed subcutaneous panniculitis-like T-cell lymphoma, confirmed through immunohistochemistry analysis.
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