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Amplatzer Vascular Plug (AVP) is a device recently proposed for extra-cardiac procedures such as arterial and venous embolisation. In this paper, we assess the usefulness of AVP in emergency embolisation presenting our preliminary experience and reviewing the Literature. During the last year, we selected 31 patients for embolisation using AVP. The following nine procedures were performed in emergency (8 males, mean 72.4 years, range 57-85): four ruptured abdominal aortic aneurysm, one traumatic hepatic pseudoaneurysm with arterio-portal fistula, one carotid pseudoaneurysm due to neoplastic erosion, one renal tumor with active bleeding, one ruptured isolated iliac aneurysm and one ruptured hypogastric aneurysm. We used a total of 13 AVPs. The follow-up was carried out by computed tomography angiography (CTA) and/or contrast-enhanced ultrasound (CEUS), 3 months after the procedure and then every 3 months. We obtained immediate technical success in all nine cases. No rupture or dissection of the treated arteries occurred. We observed only an asymptomatic spasm. During a mean follow-up of 5.3 months (range 3-12 months), CTA and/or CEUS showed complete occlusion of the treated arteries. The AVP is useful in some emergency settings. In the authors' experience, the device allows precise, controlled release and can be deployed to the target more rapidly than other traditional methods. The device cannot be used in all patients due to limited ability to negotiate tortuous vessels and limited size availability. In our institution, the AVP is less expensive than alternatives. In our experience and as reported in the early literature, the device is easy to use, versatile, and achieved a high technical success rate. Further studies may confirm the effectiveness and demonstrate additional indications.
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http://dx.doi.org/10.1007/s10140-007-0696-8 | DOI Listing |
Pediatr Nephrol
September 2025
Pediatric Nephrology Department, Biobizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
Copeptin, a stable glycopeptide derived from the precursor of arginine vasopressin (AVP), has emerged as a valuable surrogate biomarker for AVP due to its stability and ease of measurement. This narrative review explores the physiological role of copeptin, its utility as a diagnostic and prognostic biomarker in different kidney diseases, and its clinical relevance in renal tubular disorders. The clinical application of copeptin as a diagnostic biomarker is best established in the differential diagnosis of polyuria-polydipsia syndrome (PPS), distinguishing nephrogenic diabetes insipidus (NDI) from central diabetes insipidus (CDI) and primary polydipsia (PP).
View Article and Find Full Text PDFUnlabelled: Complex behavioral phenotypes, such as social status, emerge from the genome across biological levels, with many of the fundamental neural mechanisms shared across vertebrates. While various aspects of the brain have been implicated in modulating social behavior, critical regulators include cells of the preoptic area (POA) and hypothalamus, which by applying cellular- resolution transcriptomic approaches allows for greater exploration of cellular dynamics in these cells. Yet, how complex gene networks function between and within cell types to regulate complex social behavior is still poorly understood.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Emergency Department, Guangdong Province Hospital of Chinese Medicine, Guangzhou, China.
Background: Nocturia is a common and bothersome symptom in the elderly population, significantly impacting their quality of sleep and overall well-being. Heat-Sensitive moxibustion (HSM) is effective for elderly people with nocturia, but its efficacy has not been scientifically proven. This randomized controlled trial is designed to determine the efficacy and safety of HSM in the elderly with Nocturia.
View Article and Find Full Text PDFBMC Endocr Disord
August 2025
Department of Endocrinology and Metabolism, Japanese Red Cross Society Kyoto Daiichi Hospital, 15-749, Honmachi, Higashiyama-ku, Kyoto, 605-0981, Japan.
Background: Cushing's syndrome (CS) during pregnancy is a rare condition associated with significant maternal and fetal complications, including hypertension, diabetes, preeclampsia, and preterm birth. Diabetes insipidus (DI) in pregnancy is a rare but often diagnosed condition, and its effective management is crucial for maintaining maternal health during pregnancy and childbirth. This case report describes the rare coexistence of DI and CS during pregnancy, highlighting the unique complexities in diagnosis and management.
View Article and Find Full Text PDFReports (MDPI)
July 2025
Department of Anesthesiology and Intensive Care, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Background and Clinical Significance: Shock in pediatric patients remains a leading cause of morbidity and mortality, with refractory cases posing significant challenges. While catecholamines like norepinephrine and epinephrine are standard vasopressors, vasopressin (AVP) has emerged as a potential adjunct therapy. However, its role in pediatric shock remains controversial due to concerns about efficacy, safety, and appropriate use.
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