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Tuberculosis of the nose is very rare. When it does occur, it almost always arises secondary to primary pulmonary tuberculosis. Nasal tuberculosis is most common in women older than 20 years. We report the case of a 16-year-old girl who presented with epistaxis, fever, submental swelling, and enlargement of multiple cervical and axillary lymph nodes. The patient was diagnosed with tuberculous granuloma of the nose and tuberculous lymphadenopathy. She was successfully treated with a 6-month regimen of standard antituberculous therapy.
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mBio
August 2025
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Unlabelled: Tuberculosis, a persistent public health challenge worldwide, is transmitted when exhaled (Mtb) particles expelled from an infected individual are inhaled by a susceptible person. To study the adaptation of Mtb during transition between hosts, we developed a transmission simulation system (TSS) that combines controlled pathogen aerosolization and measurement of bioaerosol particle characteristics with in-flight sampling of Mtb and infection of mice by nose-only exposure. Using scattered-light spectrometry, we demonstrated that Mtb aerosol concentrations generated by the TSS better represented human cough than the aerosol concentrations produced by a full-body inhalation exposure system commonly used for Mtb infection of mice.
View Article and Find Full Text PDFIndian J Pediatr
July 2025
Pediatric Intensive Care, Bai Jerbai Wadia Hospital for Children, Parel, Mumbai, 400012, India.
Microb Pathog
October 2025
Department of Biological Sciences (Pharmacology and Toxicology), National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, 500037 India. Electronic address:
Tuberculosis (TB) is one of the major life-threatening diseases caused by a single pathogen which has become a social menace owing to its high resistance. TB has even surpassed AIDS prior the COVID 19 pandemic. Every year the number of affected persons is increasing exponentially.
View Article and Find Full Text PDFFront Public Health
May 2025
Health Promotion Unit, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Introduction: Healthcare personnel (HCP) face high risks of airborne infections, including coronavirus disease 2019 (COVID-19), tuberculosis, and measles. Filtering facepiece respirators (FFRs) are critical for protection but require an adequate fit for effectiveness. Limited studies have explored the fit performance of different FFR designs in Southeast Asian populations.
View Article and Find Full Text PDFMed Arch
May 2025
University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major global health problem, with one-third of the world's population infected.
Objective: This report presents five cases of tuberculous meningitis with a particular emphasis on the symptoms and signs of otitis media that, in various combinations, should raise suspicion for tuberculous meningitis.
Case Presentation: These cases underscore the diagnostic challenges and clinical complexities associated with tuberculous otitis media, particularly when there is concurrent involvement of the central nervous system.