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Objective: To improve the detection and control of infectious diseases in Guangxi, China.
Setting/participants: Guangxi province in southwest China has almost 50 million people, of whom approximately 30% reside in urban and 70% in rural areas. There are 12 minority nationality groups living in the region.
Intervention: A village doctor reports any infectious disease outbreak to the Reporting Network, which notifies the Service Network to organize the clinical response. This is supported by the Government Network that coordinates the response among the multiple layers of local governments.
Outcomes: Since 2002 when the Three Networks system was first started, the time from incidence to report has been shortened on average from 30.6 to 7.6 days and the number of cases has increased from slightly less than 5000 cases/year (4965) to almost 10,000 cases/year (9873). Average mortality has decreased from 3.23% to 0.74%. The Three Networks system has been successful in controlling measles outbreaks; and during SARS, when 11 cases came to Guangxi from the neighbouring Guangdong province, there were only 11 additional new cases with no community spread and no spread to medical staff.
Conclusion: The Three Networks system has played an important role in infectious disease prevention and control in Guangxi province, and may be applicable to other areas with a similar situation.
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http://dx.doi.org/10.1007/BF03405350 | DOI Listing |
Mol Syst Biol
September 2025
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Vascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the epigenomic and transcriptomic underpinning of vascular site-specific disease risk is largely unknown. Here, we performed single-cell chromatin accessibility (scATACseq) and gene expression profiling (scRNAseq) of mouse vascular tissue from three vascular sites. Through interrogation of epigenomic enhancers and gene regulatory networks, we discovered key regulatory enhancers to not only be cell type, but vascular site-specific.
View Article and Find Full Text PDFNat Methods
September 2025
Electron Microscopy Science Technology Platform, The Francis Crick Institute, London, UK.
Volume correlative light and electron microscopy (vCLEM) is a powerful imaging technique that enables the visualization of fluorescently labeled proteins within their ultrastructural context. Currently, vCLEM alignment relies on time-consuming and subjective manual methods. This paper presents CLEM-Reg, an algorithm that automates the three-dimensional alignment of vCLEM datasets by leveraging probabilistic point cloud registration techniques.
View Article and Find Full Text PDFJ Safety Res
September 2025
School of Humanities and Social Sciences, Fuzhou University, Fuzhou 350116, China. Electronic address:
Introduction: Listening to music while driving is a common practice. Extensive research has explored its effects on driving performance, with a growing consensus suggesting that the optimal complexity of music varies depending on different driving scenarios to maintain drivers' arousal levels. However, these optimal levels can vary significantly among individuals.
View Article and Find Full Text PDFJ Safety Res
September 2025
Institute for Traffic Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Introduction: The continuous progression of autonomous driving technology is propelling the automotive industry into an unprecedented era, with the intelligence and driving safety capabilities of autonomous vehicles serving as crucial benchmarks for assessing industry development. However, crashes involving autonomous vehicles have raised concerns among both government authorities and the general public regarding this technology. Consequently, conducting a comprehensive analysis of crash causes and key causal factors holds immense significance for technological progress, personnel safety, and shaping the future direction of the automotive industry.
View Article and Find Full Text PDFJ Safety Res
September 2025
Operations Analysis and Essential Data, TriMet, United States.
Unlabelled: Recent research highlights significant shifts in travel patterns, traffic volumes, and safety measures due to the COVID-19 pandemic. Early findings suggest a nationwide decrease in crashes (22.0%) and injuries (16.
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