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Surgical treatments of aortic root involvement in aortitis syndrome are frequently complicated by valve detachment and pseudoaneurysmal formation during active inflammation. A 40-year-old woman with aortitis syndrome complicating the ascending aortic aneurysm, severe aortic regurgitation (AR), and left coronary ostial stenosis was successfully treated by aortic root replacement and concomitant coronary artery bypass grafting (CABG) during acute inflammation. We devised an intravalvular implantation between the fragile aortic annulus and Teflon felt to a modified Bentall's procedure, which prevented anastomotic leakage and pseudoaneurysmal formation in the late period.
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Rev Clin Esp (Barc)
September 2025
Servicio de Medicina Interna, Unidad de Ecografía Clínica, Hospital San Carlos, San Fernando, Cádiz, Spain. Electronic address:
BMJ Case Rep
September 2025
Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India
Renal involvement in Takayasu arteritis (TA) has been reported, but glomerular lesions causing nephrotic syndrome (NS) are rare. This is a case report of TA presenting with NS due to secondary amyloidosis.A woman in her late 40s was diagnosed as TA at the age of 15 years presented with nephrotic range proteinuria.
View Article and Find Full Text PDFJACC Case Rep
August 2025
Department of Radiology, Hospital México, San José, Costa Rica.
Case Summary: A 20-year-old woman presented with acute coronary syndrome. Invasive coronary angiography revealed complete occlusion of the left main coronary artery. Subsequent computed tomography angiography demonstrated occlusion of the left subclavian, left vertebral, and superior mesenteric arteries, along with circumferential thickening of the abdominal aorta, consistent with Takayasu arteritis.
View Article and Find Full Text PDFJACC Case Rep
August 2025
Paediatric Cardiothoracic Department, Alder Hey Children's Hospital, Liverpool, United Kingdom. Electronic address:
Background: Takayasu arteritis (TA) is a large-vessel vasculitis that primarily affects the aorta and the pulmonary and coronary arteries.
Case Summary: A 4-year-old boy was diagnosed in 2022 with pyoderma gangrenosum (PG) and required prolonged multidisciplinary care, including aggressive medical immunosuppression for severe skin lesions. In October 2024, after a period of clinical stability, he presented with a seizure and right-sided weakness.
Autoimmun Rev
August 2025
Departments of Medicine and Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Canada; Population Health Research Institute, Hamilton Health Sciences / McMaster University, Hamilton, Canada. Electronic address:
The fragility of randomized controlled trials (RCTs) of large vessel vasculitis (LVV) - defined as the minimum number of outcome events that would need to change to reverse the trial's conclusions - has not been comprehensively studied. We identified relevant RCTs with a systematic literature review till April 2025. The fragility index (FI)/ reverse fragility index (RFI) and fragility quotient (FQ, i.
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