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25 Candida albicans strains have been analysed on Southern hybridization patterns with alpha, beta, gamma, kappa probes. The alpha, beta, gamma, kappa, elements can be used to distinguish the differences and relations between C. albicans strains. Chromosomal localization analysis indicated that the alpha, beta, gamma, kappa, elements were located on several different chromosomes in Candida albicans strains. Northern hybridization showed that alpha, beta, gamma were transcribed actively and regulated by different stimuli. The kappa was inactive. Our results indicated that in Candida albicans there were many kinds of retroposons whose numbers and distribution were different. These retroposons could be used to identify Candida albicans strains as moleculer markers.
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J Med Microbiol
September 2025
Department of Microbiology, Meiji Pharmaceutical University, Tokyo, Japan.
Biofilms are a primary form of device-associated infections and typically exhibit high tolerance to antimicrobial agents. In biofilms formed by multiple microbial species, microorganisms may show even greater tolerance, complicating treatment. There is evidence that meropenem (MEPM) tolerance in is increased in dual-species biofilms with , and effective treatments have not been established.
View Article and Find Full Text PDFCancer Pathog Ther
September 2025
Department of Microbiology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.
Oral cancer pathogenesis is significantly influenced by species, especially , through chronic inflammation and cellular dysregulation. Epidemiological studies highlight a strong correlation between persistent infections and oral carcinogenesis. Experimental evidence has identified key biomolecular mechanisms, including biofilm formation, epithelial invasion, and immune evasion.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
Mardin Artuklu University, Kızıltepe Faculty of Agricultural Sciences and Technologies, Department of Field Crops, Mardin, Artuklu, 47200, Türkiye.
Objective: This study was conducted to determine and compare the antioxidant, cytotoxic, and antimicrobial effects of spindle leaves of L. () (oleaster) leaves.
Methods: Total phenolic content was measured using the Folin-Ciocalteu method, phenolic compound analysis by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and antimicrobial effect by the minimum inhibition concentration (MIC) method.
BMC Microbiol
September 2025
Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo, 11421, Egypt.
Background: The emergence of drug-resistant pathogens has stimulated the need for the development of new antimicrobial agents. Epigenetic modulation by suppressing epigenetic inhibitors, such as 5-azacytidine (5-aza), has been shown to activate silent biosynthetic gene clusters within a fungus and causes the production of novel secondary metabolites. This research examined this epigenetic modification strategy in the poorly studied filamentous fungus, Ceratorhiza hydrophila, which may help induce the additional production of bioactive compounds.
View Article and Find Full Text PDFmBio
September 2025
School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
In the opportunistic pathogen , hyphal growth and virulence factor expression are regulated by environmental and chemical cues. Farnesol is a secreted autoregulatory molecule that represses filamentation. It is derived from farnesyl pyrophosphate (FPP), an ergosterol biosynthesis pathway intermediate.
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