Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A case of pulmonary tumorlets with ectopic adrenocorticotropin (ACTH) production and lymph node metastasis in a bronchiectatic patient is reported. A 65-year-old man underwent right lower lobe lobectomy because of a sudden attack of cough and hemoptysis. Histological study revealed multiple discrete uniform small nests of tumor cells surrounding dilated bronchioles. Tumor nests were also found in the hilar lymph node. Immunohistochemically, the proliferating cells were confirmed to be neuroendocrine in origin with ectopic ACTH production, despite being clinically silent. The findings in the present case suggest that the clinical behavior of pulmonary tumorlets may be like a carcinoid, and need to be treated as tumor-like lesions. Ectopic hormonal production in the present case suggests pulmonary tumorlets should be considered in the differential diagnosis of Cushing's syndrome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1440-1827.2003.01567.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incidentally Detected Pulmonary Carcinoid Tumorlet With Coexisting Carcinoid Tumorlet in the Mediastinal Lymph Node in a Patient With Lung Cancer.
Case Rep Pulmonol
August 2025
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Pulmonary carcinoid tumorlets are a cluster of neuroendocrine cells in the lung, which invade the basement membrane and are less than 5 mm in size. While similar to carcinoid tumors in all regards, they are differentiated from carcinoid tumors purely based on their size. They are generally considered benign, but lymph nodal involvement has been described in the past.
View Article and Find Full Text PDFCentral Airway Carcinoid Tumorlets Following Resection of a Typical Carcinoid Tumor.
Diagnostics (Basel)
June 2025
Department of Pathology, School of Medicine, Gyeongsang National University, Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea.
Pulmonary neuroendocrine proliferations and neoplasms represent a broad spectrum of diseases, ranging from neuroendocrine cell hyperplasia and tumorlets to carcinoid tumors. Carcinoid tumorlets are most commonly located in the peripheral airways and are often incidentally detected as pulmonary micronodules on chest CT. We report the radiological, bronchoscopic, and pathological findings of a case of carcinoid tumorlets presenting as endobronchial nodules in the left main bronchus.
View Article and Find Full Text PDFVariable Presentations of Sclerosing Pneumocytoma: Two Cases Highlighting Divergent Fluorodeoxyglucose Metabolism and Carcinoid Tumorlet Association.
Cureus
April 2025
Division of Pulmonary Medicine, Cooper University Hospital, Camden, USA.
Pulmonary sclerosing pneumocytomas are rare benign tumors, with some cases demonstrating potential for aggressive metastasis. Patients typically are asymptomatic with a nodule/mass seen on incidental imaging; however, they can present with nonspecific symptoms such as cough, shortness of breath, and chest pain. Diagnosis can only be confirmed with biopsy, and computed tomography-guided or fluoroscopy-guided needle biopsies are routinely used.
View Article and Find Full Text PDF[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)].
Rev Mal Respir
May 2025
Service de pneumologie et centre de référence des maladies pulmonaires rares, hôpital Bichat, AP-HP Nord-Université Paris Cité, 46, rue Henri-Huchard, 75018 Paris, France.
Introduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, chronic condition that predominantly affects women over the age of 60.
Current Knowledge: DIPNECH combines non-specific clinical signs (chronic cough, dyspnea), bronchial obstruction on PFT and signs suggestive of bronchiolitis on chest CT associated with nodules and multiple micronodules. The diagnosis is most often histological, associating neuroendocrine cell hyperplasia, tumorlets and, inconsistently, carcinoid tumors and constrictive bronchiolitis.
Recurrent transient visual loss in secretory carcinoid tumor.
Am J Ophthalmol Case Rep
June 2025
Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
Purpose: We describe a case of a 68-year-old woman who had a biopsy-proven carcinoid of the lung and transient episodes of unilateral and bilateral vision loss presumed to be the result to intermittent serum elevations of vasoactive peptides secondary to an occult carcinoid.
Observations: A 68-year-old female with history of carcinoid tumor of the lung presented with multiple recurrent and alternating unilateral and bilateral transient vision loss (TVL) which were increasing in frequency over a period of one month. Ophthalmologic examination was unremarkable.