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An aim of human factors research is to have models that allow for the advance design of user-friendly environments. This is still a distant dream because existing models are not yet sufficiently sophisticated. Models in the domain of motor control are a case in point, but recent developments in computational motor control suggest that the gap between the current state of modeling in this area and the desired state is shrinking. To illustrate this point, we review principles of motor control research that any model of motor control must accommodate. Then we describe a model that captures many of the capacities of actors in the everyday world, including the capacity to reach for objects in different ways depending on factors such as the ease with which different joints can rotate, the required speed of movement, and whether obstacles are present. The model relies on the ideas that goal postures are internally specified before movements are generated, that tasks are defined with flexibly ordered constraint hierarchies, and that movements can be shaped according to task demands. Actual or potential applications of this research include designing and testing possible environments where motor components play a key role.
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http://dx.doi.org/10.1518/hfes.45.1.5.27226 | DOI Listing |
Comput Methods Biomech Biomed Engin
September 2025
Institute of Radio Physics and Electronics, University of Calcutta, Kolkata, India.
Parkinson's disease (PD) is a neurodegenerative condition that impairs motor functions. Accurate and early diagnosis is essential for enhancing well-being and ensuring effective treatment. This study proposes a deep learning-based approach for PD detection using EEG signals.
View Article and Find Full Text PDFFront Sports Act Living
August 2025
School of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, China.
Introduction: This study examined the impacts of different negative pressure cupping therapies (PCT) on pain relief, functional recovery, and inflammatory regulation in delayed onset muscle soreness (DOMS) after high-intensity exercise, with the aim of clarifying the dose-effect relationship.
Methods: In this study, 55 healthy male participants aged 18-25 were selected and divided into 5 groups: the control group (CTR; = 11) and NPCT groups at different levels (-25 kPa, -35 kPa, -45 kPa, and -55 kPa; = 11 in each group). A high-intensity protocol, which included 6 sets of lunges, squats, and squat jumps, was adopted to induce DOMS in the quadriceps femoris.
Neuropsychiatr Dis Treat
September 2025
Department of Radiology, No. 926 Hospital, Joint Logistics Support Force of PLA, Kaiyuan, Yunnan, 661699, People's Republic of China.
Parkinson's disease (PD) represents a progressive neurodegenerative disorder with escalating global burden, with mechanistic studies revealing α-synuclein propagation through gut-brain axis, mitochondrial defects, and neuroinflammatory cascades driven by genetic-environmental interplay. Recent advancements in diagnostic paradigms have successfully combined α-synuclein seed amplification assays with multimodal neuroimaging techniques, achieving an impressive diagnostic accuracy of 92% during the prodromal stages of disease. Phase II trials highlight disease-modifying potential of α-synuclein-targeting immunotherapies (40% reduction in motor decline) and LRRK2 kinase inhibitors showing blood-brain barrier penetration.
View Article and Find Full Text PDFAnn Clin Transl Neurol
September 2025
23andMe, Inc., Sunnyvale, California, USA.
Objective: To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts, USA.
Background: Examining youth before engagement in risky behaviors may help identify neurobiological signatures that prospectively predict susceptibility to initiating and escalating alcohol and other substance use. Given that frontal and medial temporal (e.g.
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