Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Matrix metalloproteinases are proteolytic enzymes that degrade extracellular matrix components. Numerous studies have demonstrated that individual MMPs play a crucial role in tumor invasion and metastasis.
Objective: To examine the expression of MMPs and their inhibitor TIMP-2 in neoplastic and normal thyroid tissues.
Methods: We examined 33 cases of thyroid tumor (papillary, follicular and medullary carcinoma, follicular adenoma and multinodular goiter). MMP protein content and activity were measured by enzyme-linked immunosorbent assay and gel zymography. Immunohistochemistry was also performed.
Results: The thyroid tissues examined secreted MMP-2 and 9 as well as TIMP-2, but only MMP-2 was significantly higher in papillary carcinoma cases compared to the adjacent normal tissue or to the other tumor entities. Increased MMP-2 immunohistochemical staining was demonstrated in the neoplastic papillary epithelial component. No significant difference was seen between papillary carcinomas with lymph node metastases and those without.
Conclusions: Increased MMP-2 expression may be useful as a diagnostic marker to differentiate papillary carcinoma from other thyroid neoplasms, but it cannot serve as a useful prognostic marker.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nitrous oxide (N2O) recreational use is increasing across Germany - a survey of the German neurological society among practicing neurologists.
Neurol Res Pract
September 2025
German Neurological Society, Berlin, Germany.
Background: Recreational nitrous oxide (NO) abuse has become increasingly prevalent, raising concerns about associated health risks. In Germany, the lack of reliable data on NO consumption patterns limits the development of effective public health interventions. This study aims to address this knowledge gap by examining trends, determinants, and health consequences of NO abuse in Germany.
View Article and Find Full Text PDFA systematic review of EEG-based machine learning classifications for obsessive-compulsive disorder: current status and future directions.
BMC Psychiatry
September 2025
Department of Cognitive Neuroscience, Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Obsessive-compulsive disorder (OCD) is a chronic and disabling condition affecting approximately 3.5% of the global population, with diagnosis on average delayed by 7.1 years or often confounded with other psychiatric disorders.
View Article and Find Full Text PDFClinical heterogeneity and prognostic markers in head and neck Kimura disease: A retrospective study.
Eur Arch Otorhinolaryngol
September 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Objective: Kimura disease (KD) is a rare, chronic inflammatory disorder that is typically located in the head and neck region. It is characterized by subcutaneous nodules, eosinophilia, and elevated IgE levels. Its unclear etiology and similarities to malignancies create diagnostic and therapeutic challenges.
View Article and Find Full Text PDFA pilot study examining a ketogenic diet as an adjunct therapy in college students with major depressive disorder.
Transl Psychiatry
September 2025
Department of Human Sciences, The Ohio State University, Columbus, OH, USA.
A ketogenic diet (KD) has shown promise as an adjunctive therapy for neurological and neuropsychiatric disorders, including bipolar disorder and major depressive disorder (MDD). We examined tolerance for a KD in young adults with MDD and assessed symptoms of depression and metabolic health. Students (n = 24) with a confirmed diagnosis of MDD at baseline receiving standard of care counseling and/or medication treatment were enrolled in a 10-12 week KD intervention that included partial provision of ketogenic-appropriate food items, frequent dietary counseling, and daily morning tracking of capillary R-beta-hydroxybutyrate (R-BHB).
View Article and Find Full Text PDF[Speech markers as objective indicators of apathy: New insights from a case study].
Encephale
September 2025
Speech and Language Pathology Department of Nice, Faculty of Medicine, Campus Pasteur, université Côte d'Azur, 28, avenue de Valombrose, 06107 Nice, France; Cognition Behaviour Technology Laboratoy (CoBTeK), institut Claude-Pompidou, université Côte d'Azur, 10, rue Molière, 06000 Nice, France.
Introduction: Apathy, commonly observed in neurocognitive disorders, is characterized by a reduction in goal-directed behavior with a reduction of initiatives interests and emotions. This article presents the case of Mrs. B.
View Article and Find Full Text PDF