Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0168-8278(01)00234-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Editorial: Progress in diagnosis and treatment of hypothalamic & pituitary disorders.
Front Endocrinol (Lausanne)
August 2025
Department of Internal Disease and Clinical Pharmacology, The Medical University of Lodz, Lodz, Poland.
Rapid Adrenal Atrophy Following Excision of an Ectopic Adrenocorticotropin-Secreting Lung Carcinoid Tumor.
JCEM Case Rep
October 2025
Division of Diabetes, Endocrinology and Metabolism, Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.
Ectopic adrenocorticotropin (ACTH) secretion, a rare cause of ACTH-dependent Cushing syndrome, may be caused by neuroendocrine tumors (NETS). Postoperative hypothalamic-pituitary-adrenal (HPA) axis suppression is expected due to prolonged ACTH and cortisol overproduction. Pituitary corticotrophs are suppressed, but the adrenals are hyperplastic, and cortisol is expected to rise exuberantly after ACTH stimulation.
View Article and Find Full Text PDFSignificance of Exogenous Estradiol on Plasma Cortisol and Salivary Cortisol During Adrenocorticotropic Hormone Stimulation in Women With Pituitary Insufficiency.
Clin Endocrinol (Oxf)
August 2025
Department of Nephrology and Endocrinology, Rigshospitalet Copenhagen, Copenhagen, Denmark.
Objective: Oral estrogens increase the levels of cortisol binding globulin (CBG) potentially affecting test results for adrenal insufficiency. The objective was to evaluate the influence of oral and transdermal estradiol on total plasma (p) and salivary cortisol in hypogonadal women with secondary adrenal insufficiency or at risk of developing adrenal insufficiency. Furthermore, to determine if estradiol treatment can lead to a change in the diagnosis of adrenal insufficiency based on a Synacthen-test.
View Article and Find Full Text PDFIncidental diagnosis of primary adrenal insufficiency precipitated by positive ABCD1 gene mutation detected on cascade screening.
BMJ Case Rep
August 2025
Diabetes, Endocrinology and General (Internal) Medicine, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire, UK
This case presentation outlines the occurrence of primary adrenal insufficiency secondary to ATP binding cassette subfamily D member 1 (ABCD1) mutation in a man in his 40s following a genetic screening test performed after a diagnosis of X-linked adrenoleukodystrophy (X-ALD) in his nephew who is in his middle childhood years. In contrast to his nephew's presentation with rapid onset and progression of cerebral adrenoleukodystrophy leading to severe neurological manifestations, his symptoms primarily included chronic fatigue and muscle stiffness without any features suggestive of mineralocorticoid deficiency noted for at least 3 years preceding the timeline of his diagnosis. Genetic testing revealed X-ALD (hemizygous for ABCD1:c901-5c>A).
View Article and Find Full Text PDFRedefining the Diagnostic Approach to Adrenal Insufficiency: Re-Assessment of Baseline and Cortisol Increment Cut-Offs with the 1 µg Synacthen Test.
Medicina (Kaunas)
July 2025
Department of Endocrinology, University Hospital of Farhat Hached, Sousse 4031, Tunisia.
Adrenal insufficiency (AI) is an endocrine disorder characterized by inadequate cortisol production, leading to non-specific symptoms that delay diagnosis. The Low Dose Synacthen Test (LDST) is commonly used to evaluate adrenal function, but traditional cortisol cut-offs may not accurately reflect adrenal function in all patients. This study aims to identify baseline cortisol cut-offs to accurately rule in and out AI, reassess the value of cortisol increment during LDST, and evaluate the accuracy of 30 and 60 min cortisol measurements in diagnosing AI.
View Article and Find Full Text PDF