Publications by authors named "Zi-Shan Dong"
Article Synopsis
- Itching is a strong sensation that leads to scratching, and the study investigates how fibroblast growth factor 13 (FGF13) affects acute and chronic itch through TRP channel proteins.
- The research found that removing FGF13 in certain neurons significantly reduced scratching behavior in response to itch models, specifically impacting the TRPV1 channel while not affecting TRPA1.
- The ability of FGF13 to modulate TRPV1 function relies on its effect on microtubules, and restoring FGF13 that can bind to tubulin was necessary for normal TRP channel function and itch responses in knockout mice.
