Global Burden and Gender Disparities in Head and Neck Cancers Among Adults Aged 40-64, 1990-2021: A Systematic Analysis From the Global Burden of Disease Study 2021.

Background: Head and neck cancer (HNC) is a significant global health concern, with incidence rising after the age of 40. This study aims to analyze the trends in prevalence, incidence, mortality, and disability-adjusted life years (DALYs), focusing on regional and gender differences.

Methods: This research utilized data from the Global Burden of Disease (GBD) 2021 study.

Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.

Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) as a crucial mitochondrial peptide that significantly influences metabolic regulation, mimics the effects of exercise, and mitigates oxidative stress. This study aims to investigate the relationship between serum MOTS-c levels and obstructive sleep apnea (OSA) to enhance our understanding of the disease's pathophysiology. By elucidating this relationship, we hope to uncover new insights into the mechanisms underlying OSA and its associated metabolic complications.