Integrative proteomics and metabolomics reveal important pathways and potential biomarkers in high-altitude pulmonary hypertension.

High-altitude pulmonary hypertension (HAPH) is a severe condition affecting highland residents, yet its molecular mechanisms remain incompletely understood. This study aimed to investigate the pathogenesis of HAPH through integrated metabolomic and proteomic analyses. We performed untargeted metabolomics and proteomics analyses on plasma samples from HAPH patients (n=30) and matched healthy controls (n=30).