Comparison between sub-lobar resection and lobar resection for clinical stage IA (tumor size ≤ 2 cm) lung invasive mucinous adenocarcinoma with tumor spread through air spaces: A multi-center real-world study.

Background: Tumor spread through air spaces (STAS) has emerged as a significant prognostic factor in clinical stage IA (cIA) invasive mucinous adenocarcinoma (IMA) of the lung. However, it remains unclear whether sub-lobar resection (SR) offers survival outcomes comparable to those of lobar resection (LR) in this cohort. This study aimed to assess the efficacy of SR in patients with STAS-positive cIA (tumor size ≤2 cm) IMA using large-scale, multi-center, real-world data.

Lobectomy Versus Sub-lobectomy for Clinical Stage IA (≤2 cm) Lung Squamous Cell Carcinoma with Tumour Spread through Air Spaces: A Multi-Centre Retrospective Study.

Objectives: The efficacy of sub-lobectomy for clinical IA (tumours ≤2 cm) lung squamous cell carcinoma with tumour spread through air spaces (STAS) remains unknown. This study compares long-term survival outcomes between sub-lobectomy and lobectomy, aiming to offer pivotal evidence for optimizing resection strategies for clinical IA STAS-positive squamous cell carcinoma patients.

Methods: Consecutive clinical IA STAS-positive squamous cell carcinoma patients undergoing surgery between 2010 and 2020 at 7 high-volume institutions across 5 Chinese cities were retrospectively reviewed.

Lobar versus sub-lobar resection for clinical stage IA (≤ 2 cm) lung neuroendocrine tumor with spread through air spaces: a multi-center study.

Tumor spread through air spaces (STAS) is an important prognostic factor for lung cancer, including lung neuroendocrine tumors (NETs). The comparative oncological efficacy of lobar resection (LR) and sub-lobar resection (SR) for clinical stage IA (cIA) STAS-positive NETs remains unclear. This retrospective study aimed to review outcomes in patients with consecutive peripheral cIA (tumors ≤ 2 cm) STAS-positive NET patients (excluding small cell lung cancer) who underwent surgery between 2012 and 2020 at six high-volume tertiary Chinese institutions.

Development of a chemically induced dissociation system via phage surface-displayed nanobody screening.

Chemical methods for controlling protein function posttranslationally in an inducible manner provide profound insights into cellular processes and are powerful tools in synthetic biology. Here, we utilized the phage display method to screen for a nanobody whose interaction with the hepatitis C virus protease NS3a can be disrupted by FDA-approved small-molecule drugs. By employing Grazoprevir as a chemical disruptor of the NS3a/nanobody interaction, we demonstrate that our chemically induced dissociation system (CIDiss) can effectively regulate protein-protein interaction in the endoplasmic reticulum in human cells.

DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs.

The rational design of PROTACs is difficult due to their obscure structure-activity relationship. This study introduces a deep neural network model - DeepPROTACs to help design potent PROTACs molecules. It can predict the degradation capacity of a proposed PROTAC molecule based on structures of given target protein and E3 ligase.