Publications by authors named "Zhize Xiao"
Weak and Tunable Adhesion-Clutch Drives Rapid Cell Migration and Glioblastoma Invasion.
Adv Sci (Weinh)
August 2025
To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin-independent forces for cell migration; however, the molecular machinery that exerts forces remains unclear. This study shows that the clutch-linker molecule shootin1 and the cell adhesion molecule L1 transmit the backward force of treadmilling actin filaments to the environment, enabling rapid dendritic cell migration.
View Article and Find Full Text PDFMedulloblastoma (MB), a common malignant pediatric brain tumor arising in the cerebellum, is characterized by mutations in chromatin modifiers, highlighting the significance of chromatin modification abnormalities in its progression. While animal models have effectively demonstrated this, a comprehensive evaluation of the oncogenic potential of these mutations remains incomplete. In this study, we use CRISPR-mediated gene editing to knock out chromatin modifier genes mutated in human SHH MB, along with the Ptch1 gene, in cerebellar granule neuron progenitors of neonatal mice.
View Article and Find Full Text PDFArticle Synopsis
- Normal cells regulate growth and maturation through precise gene expression changes influenced by the epigenome, but the epigenetic shifts during cancer progression are not well-understood.
- This study focuses on medulloblastoma, an embryonal brain tumor, and reveals key epigenomic changes that differentiate precancerous cells from malignant ones.
- It identifies the nuclear factor I (NFIB) transcription factor as a significant player in cancer development, showing that inhibiting NFIB can disrupt the cancer-specific epigenome, highlighting the role of non-mutational mechanisms in tumorigenesis.
Carmustine as a Supplementary Therapeutic Option for Glioblastoma: A Systematic Review and Meta-Analysis.
Front Neurol
September 2020
Glioblastoma (GBM) is the most aggressive type of primary malignant brain tumor. Carmustine is used by intravenous injection or local implantation in the resection cavity for gliomas, including GBMs. However, the therapeutic potential of carmustine is not well-recognized.
View Article and Find Full Text PDFPurpose: The aim of this study was to assess the neuroprotective effect of progesterone administration on severe traumatic brain injury (TBI) for different follow-up periods and administration route by completing a meta-analysis of randomized clinical trials (RCTs).
Methods: A systematic literature search of PubMed, Embase, and Cochrane databases and the Web of Science (from establishment of each to September 1, 2018) was performed to identify original RCTs that evaluated the associations between progesterone treatment and the prognosis of patients with severe TBI.
Results: Eight RCTs enrolling 2,251 patients with severe TBI were included.