Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an study.

In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. The formulation underwent various physicochemical characterization experiments, an release study, molecular simulations and was evaluated for anti-inflammatory activity. Results showed that Nio-Curc had a mean particle size of 284.

Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma.

Curcumin a component of turmeric, which is derived from Curcuma longa is used as a colouring agent and as a dietary spice for centuries. Extensive studies have been done on the anti-inflammatory activity of curcumin along with its molecular mechanism involving different signalling pathways. However, the physicochemical and biological properties such as poor solubility and rapid metabolism of curcumin have led to low bioavailability and hence limits its application.

Immunological axis of curcumin-loaded vesicular drug delivery systems.

Several vesicular systems loaded with curcumin have found their way in the therapeutic applications of several diseases, primarily acting through their immunological pathways. Such systems use particles at a nanoscale range, bringing about their intended use through a range of complex mechanisms. Apart from delivering drug substances into target tissues, these vesicular systems also effectively overcome problems like insolubility and unequal drug distribution.

The role of pazopanib on tumour angiogenesis and in the management of cancers: A review.

Pazopanib is a relatively new compound to be introduced into the chemotherapy field. It is thought to have decent anti-angiogenic properties, which gives an additional hope for the treatment of certain types of cancers. A systematic review solely discussing about pazopanib and its anti-angiogenic effect is yet to be published to date, despite several relevant clinical trials being conducted over the recent years.

Vesicular Systems Containing Curcumin and Their Applications in Respiratory Disorders - A Mini Review.

Background: Vesicular systems like nanotechnology and liposomes are gaining tremendous attention lately in the field of respiratory diseases. These formulations enhance bioavailability of the drug candidate, which could be achieved through a novel drug delivery mechanism. Moreover, the therapeutic potential achieved through these systems is highly controllable over long durations of time providing better efficacy and patient compliance.