Publications by authors named "Zhang Sen Di Chen"
Bioinformatic analysis of biological changes involved in pelvic organ prolapse.
Medicine (Baltimore)
June 2023
Article Synopsis
- The study investigates the molecular mechanisms behind pelvic organ prolapse (POP) by analyzing differentially expressed genes (DEGs) from various datasets to identify key molecules involved in its pathogenesis and progression.
- The analysis revealed 92 upregulated DEGs related to hormonal responses, cell death regulation, and extracellular matrix processes, with significant enrichment in the phosphatidylinositol 3-kinase-AKT signaling pathway.
- Ten hub genes such as CDKN1A and IL-6 were identified, and the findings also indicated an increase in CD8-positive T cells in POP patients, suggesting a link between immune response and the condition.