Possible utilization of salivary IFN-γ/IL-4 ratio as a marker of chronic stress in healthy individuals.

Introduction: Several studies show that psychological stress reduces Th1/Th2 ratio in blood samples. However, evidence is scarce regarding the cytokine alterations during stress in saliva. We investigated the influence of chronic stress on Th1/Th2 ratio and cytokine profiles in the saliva of healthy individuals.