Publications by authors named "Yuichiro Tabunoki"
Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.
Proc Natl Acad Sci U S A
November 2019
Article Synopsis
- The study explores how the activation of immune receptors, particularly Toll-like receptor 7 (TLR7), by pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs), is key to both fighting infections and potentially causing autoimmune disorders.
- Researchers developed a compound called KN69 that inhibits autoimmunity and discovered that a specific small nuclear RNA (U11snRNA) can activate TLR7 and trigger arthritis in experimental models.
- The findings suggest that U11snRNA plays a significant role in autoimmune diseases, and insights gained from this research could help develop new therapies targeting TLR7 for various immune-related conditions.
In this study, we examined osteopontin (OPN) production in myeloma cells and plasma OPN levels in multiple myeloma (MM) patients. We assessed OPN production in bone marrow cells (BMCs) by immunocytochemistry and enzyme-linked immunosorbent assay (ELISA). We also assessed OPN production in various B-cell malignant cell lines, including three myeloma cell lines by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting.
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