Publications by authors named "Yuan-Ting Chuang"
MicroRNA 29a alleviates mitochondrial stress in diet-induced NAFLD by inhibiting the MAVS pathway.
Eur J Pharmacol
November 2024
Article Synopsis
- * MicroRNA-29a (miR-29a) shows promise in combating liver damage by reducing fibrosis and oxidative stress, especially in models fed a Western diet, with results indicating improved liver health and lower cholesterol levels in mice.
- * The study reveals that miR-29a works by inhibiting the MAVS signaling pathway, decreasing mitochondrial double-stranded RNA release, and could enhance the treatment of NAFLD and liver steatofibrosis.
MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice.
Biochem Biophys Res Commun
February 2018
Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysaccharide, both of which participate in activating hepatic stellate cells and liver fibrosis.
View Article and Find Full Text PDFCelecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can elicit anti-tumor effects in various malignancies. Here, we sought to clarify the role of autophagy in celecoxib-induced cytotoxicity in human urothelial carcinoma (UC) cells. The results shows celecoxib induced cellular stress response such as endoplasmic reticulum (ER) stress, phosopho-SAPK/JNK, and phosopho-c-Jun as well as autophagosome formation in UC cells.
View Article and Find Full Text PDFCelecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that has been reported to elicit anti-proliferative response in various tumors. In this study, we aim to investigate the antitumor effect of celecoxib on urothelial carcinoma (UC) cells and the role endoplasmic reticulum (ER) stress plays in celecoxib-induced cytotoxicity. The cytotoxic effects were measured by MTT assay and flow cytometry.
View Article and Find Full Text PDFObjective: This study aimed to assess stathmin expression in benign and malignant phaeochromocytomas and paragangliomas.
Methods: Tissue specimens from 37 patients with malignant phaeochromocytomas (n = 5), malignant paragangliomas (n = 3), benign phaeochromocytomas (n = 24), and benign paragangliomas (n = 5) were analysed for stathmin expression by western blotting and immunohistochemical staining with polyclonal antibodies. Malignancy was defined by metastases in nonchromaffin tissues.