Publications by authors named "Yuan-Dan Zhao"
Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis.
Alzheimers Res Ther
February 2025
Background: Abnormal microglial polarization phenotypes contribute to the pathogenesis of Alzheimer's disease (AD). Circular RNAs (circRNAs) have garnered increasing attention due to their significant roles in human diseases. Although research has demonstrated differential expression of circRNAs in AD, their specific functions in AD pathogenesis remain largely unexplored.
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- * The study hypothesized that introducing external mitochondria could help improve cognitive function impaired by neuroinflammation, specifically tested in LPS-treated mice.
- * Results indicated that mitochondrial treatment enhanced cognitive performance, reduced neuronal damage, and decreased inflammatory cytokine levels in the brains of these mice, suggesting a potential therapeutic approach for neuroinflammation-induced cognitive issues.
Ameliorative Role of Mitochondrial Therapy in Cognitive Function of Vascular Dementia Mice.
J Alzheimers Dis
February 2024
Background: Mitochondrial dysfunction plays a vital role in the progression of vascular dementia (VaD). We hypothesized that transfer of exogenous mitochondria might be a beneficial strategy for VaD treatment.
Objective: The study was aimed to investigate the role of mitochondrial therapy in cognitive function of VaD.
Article Synopsis
- * Findings indicate that Gli reduces neuronal cell death and cognitive decline in aging models, suggesting it may protect against age-related cognitive issues.
- * The research points to the p38 MAPK pathway as a critical target for Gli's antioxidant effects, reinforcing its potential as a therapeutic option for aging-related cognitive impairment.
Circular RNAs: emerging players in brain aging and neurodegenerative diseases.
J Pathol
January 2023
Brain aging is closely related to neurodegenerative diseases. Circular RNAs (circRNAs) are a type of conserved RNAs with covalently closed continuous loops. Emerging evidence has shown that circRNAs are implicated in the biology of brain aging and the pathology of age-related neurodegenerative diseases.
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