Consumption of ultra-processed foods has been linked to various adverse health effects; however, the mechanisms underlying these effects remain poorly understood. This study aimed to evaluate the impact of a single ultra-processed meal on myocardial blood flow (MBF), measured using positron emission tomography/computed tomography (PET/CT), and its effects on cognitive performance. Fourteen healthy adult males were enrolled in a randomized crossover trial, receiving either a non-ultra-processed meal (comprising foods from NOVA groups 1 to 3) or an ultra-processed meal (comprising foods from NOVA groups 1 to 4) before crossing over to the alternate meal.
View Article and Find Full Text PDFIntroduction: Ventilation-perfusion (V/Q) nuclear scintigraphy remains a vital diagnostic tool for assessing pulmonary embolism (PE) and other lung conditions. Interpretation of these images requires specific expertise which may benefit from recent advances in artificial intelligence (AI) to improve diagnostic accuracy and confidence in reporting. Our study aims to develop a multi-center dataset combining imaging and clinical reports to aid in creating AI models for PE diagnosis.
View Article and Find Full Text PDFWe present the case of a 67-year-old man undergoing immunosuppressive therapy with known pulmonary blastomycosis who presented with knee swelling and fever. FDG-PET/CT performed to exclude septic arthritis revealed increased uptake within the right epididymis and multiple osteoarticular, cutaneous, and subcutaneous sites. Cultures obtained from bronchoalveolar lavage, urine, right knee arthrocentesis, and subcutaneous tissue all demonstrated Blastomyces dermatitidis , compatible with disseminated blastomycosis (DB).
View Article and Find Full Text PDFJ Nucl Cardiol
December 2024
Myocardial inflammation plays a central role in the pathophysiology of various cardiac diseases. While FDG-PET is currently the primary method for molecular imaging of myocardial inflammation, its effectiveness is hindered by physiological myocardial uptake as well as its propensity for uptake by multiple disease-specific mechanisms. Novel radiotracers targeting diverse inflammatory immune cells and molecular pathways may provide unique insight through the visualization of underlying mechanisms central to the pathogenesis of inflammatory cardiac diseases, offering opportunities for increased understanding of immunocardiology.
View Article and Find Full Text PDFSarcoidosis Vasc Diffuse Lung Dis
March 2024
Backgrounds: High-degree atrioventricular block (AVB) recovery in CS has been shown to be highly variable despite immunosuppressive treatment, with no reliable tool available to predict odds of reversibility. This study sought to evaluate the potential of combined fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and resting myocardial perfusion imaging (rMPI) to predict reversibility of newly diagnosed high-grade AVB in cardiac sarcoidosis (CS).
Methods: We performed a single-center, retrospective analysis of patients with CS presenting with high-grade AVB who underwent combined FDG-PET/CT and rMPI.
We present the case of a 65-year-old woman with known pulmonary and muscular sarcoidosis who presented with dyspnea. FDG-PET/CT revealed unsuspected active myositis of multiple muscle groups, including the neck, and was useful in monitoring treatment response.
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