Exome and transcriptome analysis link calcium channel pathway aberrations to botulinum toxin A resistance in Hailey-Hailey disease.

Background: The effectiveness of botulinum toxin A (BoNTA) in the treatment of Hailey-Hailey disease (HHD) has shown heterogeneity in recent studies. However, there is currently no research investigating the underlying mechanism behind the variability in patient response.

Objectives: To identify potential biomarkers and elucidate the underlying mechanisms of the heterogeneity in efficacy of BoNTA treatment for HHD.

Highly efficient adsorption and mechanism of alkylphenols on magnetic reduced graphene oxide.

The influence of alkylphenols to environment cannot be ignored, as they are common product from chemical industries and potential threat to human health. Some alkylphenols are listed as persistent toxic substances (PTS) by the United Nations Environment Programme (UNEP). In this study, the optimized magnetic reduced graphene oxide (MrGO) was synthesized by a facile solvothermal method, and investigated for adsorption of three typical alkylphenols.

Magnetic solid phase extraction of heterocyclic aromatic hydrocarbons from environmental water samples with multiwalled carbon nanotube modified magnetic polyamido-amine dendrimers prior to gas chromatography-triple quadrupole mass spectrometer.

Present study described a sensitive and efficient method for determination of heterocyclic aromatic hydrocarbons using multiwalled carbon nanotubes modified magnetic polyamido-amine dendrimers (MNPs@PAMAM-Gn@MWCNTs) as adsorbent for magnetic solid-phase extraction (MSPE) coupled with gas chromatography-triple quadrupole mass spectrometer (GC-MS/MS). Some pivotal parameters including PAMAM generation, adsorbent dosage, adsorption time, elution time and volume, pH and humic acid concentration were investigated to achieve the best adsorption efficiencies. Under the optimal conditions, 7-methylquinoline, dibenzothiophene and carbazole had good linearity in the concentration range of 0.

Simultaneous enrichment and determination of cadmium and mercury ions using magnetic PAMAM dendrimers as the adsorbents for magnetic solid phase extraction coupled with high performance liquid chromatography.

In present study, a sensitive and efficient method based on magnetic PAMAM dendrimers as the sorbents for magnetic solid-phase extraction (MSPE) coupled with high performance liquid-phase chromatography and ultraviolet variable wavelength detector (HPLC-VWD) was developed for simultaneous determination of trace cadmium and mercury ions. Sodium diethyldithiocarbamate (DDTC-Na) was used as the chelating agent during the elution process. Parameters that would affect the extraction efficiency including PAMAM generation, adsorbent dosage, adsorption time, elution time and volume, pH and coexisting ions were investigated to achieve the best adsorption efficiency.

Enrichment and sensitive determination of phthalate esters in environmental water samples: A novel approach of MSPE-HPLC based on PAMAM dendrimers-functionalized magnetic-nanoparticles.

Phthalate esters (PAEs) are an important kind of environmental endocrine disrupting chemicals, and have attracted great attention in environmental field. Present study described a new method for rapid and sensitive determination of PAEs including dibenzyl phthalate (DPhP), dibutyl phthalate (DnPP), and dicyclohexyl phthalate (DCHP) from aqueous matrices based on magnetic solid-phase extraction. Polyamidoamine (PAMAM) dendrimers-grafted magnetic-nanoparticles were synthesized and characterized, and the expected integration of more multifunctional sites of PAMAM dendrimers and rapid separation property was utilized for method development.

A highly sensitive and selective chemosensor for 2,4,6-trinitrophenol based on L-cysteine-coated cadmium sulfide quantum dots.

2,4,6-Trinitrophenol (TNP) is a common explosive and widely used in military, pharmaceutical, pesticide, printing and dyeing industries. TNP in the wastewater and waste residues will enter into the environment by various ways and lead to serious threat on the environment. It is urgent to develop simple and robust analytical methods for highly sensitive and selective determination of TNP.

Polyamidoamine dendrimer decorated nanoparticles as an adsorbent for magnetic solid-phase extraction of tetrabromobisphenol A and 4-nonylphenol from environmental water samples.

Polyamidoamine dendrimer decorated FeO magnetic nanoparticles were successfully synthesized by Michael addition with methyl acrylate and amidation with ethylenediamine. The decorated magnetic particles were utilized as an effective adsorbent for magnetic solid-phase extraction of tetrabromobisphenol A and 4-nonylphenol at trace levels from environmental water samples. A number of parameters such as generation number, ionic strength, adsorbent dosage, eluent, adsorption time, elution volume, elution time, pH, humic acid and sample volume were optimized.

Investigation of nanoscale zerovalent iron-based magnetic and thermal dual-responsive composite materials for the removal and detection of phenols.

In this study, well-defined magnetic and thermal dual-responsive nanomaterials were synthesized, which contained ultrafine core-shell Fe@SiO nanoparticles as magnetic core and poly(N-isopropylacrylamide) (PNIPAM) as thermosensitive outer shell. The fabricated nanoparticles were characterized and investigated for the adsorption of four phenolic compounds, including bisphenol A (BPA), tetrabromobisphenol A (TBBPA), 4-tert-octylphenol (4-OP) and 4-n-nonylphenol (4-NP). The experimental results demonstrated that the excellent adsorption rates were attributed to hydrophobic effect, hydrogen-bonding interaction, and electrostatic attraction.

Iron-based magnetic molecular imprinted polymers and their application in removal and determination of di--pentyl phthalate in aqueous media.

Iron-based magnetic molecular imprinted polymers (Fe@SiO@MIP) were synthesized for highly selective removal and recognition of di--pentyl phthalate (DnPP) from water. Well-defined core-shell Fe@SiO nanoparticles (less than 70 nm) were decorated on MIPs reticular layers to endow DnPP-MIPs with magnetic property for the first time. Five other phthalic acid esters including dimethyl phthalate, diethyl phthalate, dipropyl phthalate, di--butyl phthalate and di-iso-octyl phthalate were used to investigate the adsorptive selectivity to DnPP.

Simultaneous determination of cadmium, lead and mercury ions at trace level by magnetic solid phase extraction with Fe@Ag@Dimercaptobenzene coupled to high performance liquid chromatography.

Pollution resulted from heavy metal ions have absorbed much attention, and it is of great importance to develop sensitive and simultaneous determination method for them with common technologies without highly sensitive instruments. We prepared a new and functional core-shell magnetic nano-material, Fe@Ag@dimercaptobenzene (Fe@Ag@DMB), by a one-step method with sodium borohydride as the reducing agent and transmission electron microscopy (TEM) and energy dispersive spectrometer (EDS) were used for characterisation. The mercapto functional groups on the newly synthesised magnetic nanoparticles could interact with Cd, Pb, and Hg ions in water samples and then efficient extraction for Cd, Pb, and Hg ions was achieved.

Sensitive determination of typical phenols in environmental water samples by magnetic solid-phase extraction with polyaniline@SiO @Fe as the adsorbents before HPLC.

A novel magnetic core-shell material polyaniline@SiO @Fe (PANI@SiO @Fe) has been successfully synthesized and investigated as an effective adsorbent for the magnetic solid-phase extraction of typical endocrine disrupting compounds such as bisphenol A, tetrabromobisphenol A, and 4-nonylphenol from water samples. The morphology of the as-prepared PANI@SiO @Fe was characterized by transmission electron microscopy and X-ray diffraction. The main parameters that influenced the enrichment performance such as the kind of eluent, amount of adsorbent, volume of eluent, adsorption time, elution time, ionic strength, pH, concentration of humic acid, and sample volume were investigated.

Magnetic solid phase extraction of typical polycyclic aromatic hydrocarbons from environmental water samples with metal organic framework MIL-101 (Cr) modified zero valent iron nano-particles.

Metal-organic framework material has been paid more attention because of its good physical and chemical properties. Nanoscale zero valent iron is also in the center of concern recently. Combination of their merits will give impressive results.