Publications by authors named "Ying-Tao Cui"
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction.
Acta Pharmacol Sin
March 2024
Article Synopsis
- Malignant ventricular arrhythmias (VA) following a myocardial infarction (MI) are linked to changes in heart electrical properties, and BRG1 plays a key role in this remodeling process.* -
- The study involved creating a mouse model of MI and using various techniques, including ECG monitoring and optical voltage mapping, to analyze the effects of BRG1 on ion channel behavior and cardiac function.* -
- Findings reveal that increased BRG1 expression after MI worsens the heart's electrical stability, while knocking down BRG1 improves conduction speed and heart rhythm, suggesting its potential as a therapeutic target for arrhythmias post-MI.*
Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme, emerges as a key epigenetic regulator with significant impact on the development and progression of cardiovascular disorders. From the perspective of epigenetic regulation of cardiovascular diseases, BRG1 emerges as a pivotal SWI/SNF chromatin remodeling enzyme, functioning as a key epigenetic regulator.
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- PFI-3 is a newly developed small-molecule inhibitor that selectively targets BRGs, showing potential as a therapeutic agent, though its effects on vascular function needed investigation.
- In experiments using a microvascular tension measurement device and fluorescence techniques, PFI-3 was found to cause relaxation in rat mesenteric arteries in response to various constrictors, without being influenced by certain blockers.
- The results indicated that PFI-3 reduces calcium influx and the activity of L-type voltage-dependent calcium channels in arterial smooth muscle cells, contributing to its vasodilatory effects.