Mechanisms of Resistance to Tyrosine Kinase Inhibitors in Myeloid Leukemias.

Tyrosine kinase inhibitors (TKIs) have transformed outcomes in chronic myeloid leukemia (CML) and FLT3-mutated acute myeloid leukemia (AML), yet durable remissions are curtailed by the emergence of drug resistance. This review summarizes the principal mechanisms that underlie that resistance. In CML, the most common mechanism is the development of point mutations in the BCR::ABL1 kinase domain (KD).

A case of familial hypertriglyceridemia associated with a novel heterozygous AGPAT2 mutation.

Introduction And Importance: Severe hypertriglyceridemia is increasingly leading to referrals to endocrinology clinics. Patients commonly present with clinical manifestations such as recurrent abdominal pain, acute pancreatitis, and eruptive xanthomas.

Case Presentation: We report the case of a young male patient with over 30 recurrent episodes of acute pancreatitis and extremely elevated triglyceride levels.

Outcomes of Patients with Hematological Malignancies Admitted to the Intensive Care Unit at a Tertiary Care Center in Saudi Arabia.

Background: Patients with hematological malignancies (HM) are at risk for complications, including neutropenia and admission to the intensive care unit (ICU). Granulocyte colony-stimulating factors (GCSF) can accelerate progenitor cells' proliferation and differentiation, and thus compensate for neutropenia. In patients with HM admitted to ICUs in Saudi Arabia, the outcome and impact of GCSF use on neutropenia duration and severity is understudied.

Factors that influence dermatology residents' choice of future subspecialty: A cross-sectional study.

Background: Factors influencing the choice of subspecialty fellowship program vary between medical specialties. In dermatology, there is a disparity in the distribution of dermatologists across fellowship programs. This study aimed to determine the factors considered by Saudi-trained dermatology residents when choosing a fellowship program to aid in promoting program characteristics and refining mentorship.

A Diagnostic Challenge: A Case of Disseminated Nocardiosis Presenting With Generalized Lymphadenopathy in a Patient With Interleukin-12 Deficiency.

Deficiency in interleukin-12 (IL-12) can result in susceptibility to opportunistic infection, with IL-12 deficiency being a rare genetic cause. is a gram-positive aerobic actinomycete that can cause disseminated and potentially lethal nocardiosis in immunocompromised patients. This report describes a 16-year-old male adolescent with IL-12 deficiency presenting with generalized lymphadenopathy due to disseminated The subject of our study is a male adolescent who exhibited clinical manifestations consistent with cholestasis.

The efficacy of part-time patching treatment for intermittent exotropia on different age groups.

Background: Intermittent exotropia (IXT) is one of the most common forms of strabismus usually seen in the pediatric age group, the prevalence of IXT is higher in Africa and the Middle East. IXT treatment strategies include both surgical and non-surgical methods, non-surgical management is preferred in general as it is less invasive and avoids the risks associated with surgery and anesthesia.

Aims: This study aims to determine the effectiveness of patching therapy for the treatment of IXT in different age groups and to compare the success of patching therapy in preventing surgery in IXT patients in different age groups.

Awareness of Pet Owners in Riyadh Regarding Pet-Related Health Risks and Their Associated Preventative Measures.

This study aims to determine the sociodemographic characteristics of pet owners and their sources of information regarding pet-related health risks. It also assesses pet owners' perception of pet-related health risks and evaluates their attitudes and practices regarding preventative measures toward pet-related health risks. A cross-sectional study was conducted in Riyadh, Saudi Arabia from September 2020 to February 2021.