Engineered exosomes improve the effects of curcumin on protecting mitochondria of neurons in Alzheimer's disease.

The synthetic DSPE-PEG-C3 peptide and DSPE-PEG-TPP were designed to modify the exosomes (EXO) by incubation, through which guide the C3/TPP-EXO to target the injured mitochondria of neurons. Then, C3/TPP-EXO was further used to encapsulate the curcumin (CUR) to enhance the solubility and bioavailability of the drug. By intravenously injected (i.