Publications by authors named "Xue-Zu Zhang"
Article Synopsis
- Respiratory syncytial virus (RSV) has seen a surge in cases among children following the relaxation of COVID-19 restrictions, prompting a study in Yunnan, China to assess differences in RSV infection characteristics pre- and post-COVID-19.
- The research included 2553 pediatric patients, analyzing various data, including demographics and clinical symptoms to identify factors associated with severe lower respiratory tract infection (SLRTI) across the two periods.
- Findings revealed a shift in RSV seasonal patterns and an increase in severe cases, older patient age, and higher clinical and laboratory indicators in post-COVID-19 children compared to those admitted before the pandemic.
Introduction: Off-season upsurge of respiratory syncytial virus (RSV) infection with changed characteristics and heightened clinical severity during the post-COVID-19 era are raising serious concerns. This study aimed to develop and validate a nomogram for predicting the risk of severe acute lower respiratory tract infection (SALRTI) in children hospitalized for RSV infection during the post-COVID-19 era using machine learning techniques.
Methods: A multicenter retrospective study was performed in nine tertiary hospitals in Yunnan, China, enrolling children hospitalized for RSV infection at seven of the nine participating hospitals during January-December 2023 into the development dataset.