Publications by authors named "Xiong-Wei Pi"
Advances and challenges in cell therapy for neuropathic pain based on mesenchymal stem cells.
Front Cell Dev Biol
February 2025
Neuropathic pain (NPP) is caused by damage to the somatosensory nervous system. Its prominent symptoms are spontaneous pain, hyperalgesia and abnormal pain. This pain is long-lasting and unbearable, seriously affecting the patient's quality of life.
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- P2X7 receptor (P2X7R) is linked to tumor progression in gastric cancer, with high expression correlating to worse clinicopathological features and overall survival in patients.
- High levels of P2X7R are associated with increased lymphatic metastasis and vascular invasion.
- Functional experiments show that activating P2X7R enhances gastric cancer cell behavior, while its antagonists can inhibit cancer cell proliferation and migration, suggesting P2X7R as a potential target for gastric cancer treatment.