Visible-light-induced three-component alkylation of 1,3,4-oxadiazoles 1,5-hydrogen atom transfer (1,5-HAT).

Herein we first reported an attractive example of visible-light-induced three-component alkylation of 1,3,4-oxadiazoles 1,5-hydrogen atom transfer. A broad range of 1,3,4-oxadiazoles, hydroxamic acid derivatives and alkenes were successfully transformed into the corresponding products in satisfactory yields. The reaction is characterized by mild reaction conditions, good functional group compatibility, broad substrate scope, and simple operation procedure.

Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells.

Atractylenolide-1 (AT-1), a natural active ingredient extracted from a, was reported to have good anti-fibrotic and anti-inflammatory effects. Osteogenic changes induced by the inflammation of valve interstitial cells (VICs) play a role in the development of calcified aortic valve disease (CAVD). This study aimed to investigate the anti-osteogenic effects of AT-1 in human VICs.