Oxymatrine Alleviates Central Post-Stroke Pain in Rats by Reducing the Inflammatory Response.

Background And Purpose: Central post-stroke pain (CPSP) is directly caused by cerebrovascular diseases that affect the central somatosensory system. It is a serious, chronic central neuropathic pain that responds poorly to first-line drugs. Oxymatrine (OMT), a monomer derived from the traditional Chinese medicine Ait.

Role of Sensory Pathway Injury in Central Post-Stroke Pain: A Narrative Review of Its Pathogenetic Mechanism.

Central post-stroke pain (CPSP) is a severe chronic neuropathic pain syndrome that is a direct result of cerebrovascular lesions affecting the central somatosensory system. The pathogenesis of this condition remains unclear owing to its extensive clinical manifestations. Nevertheless, clinical and animal experiments have allowed a comprehensive understanding of the mechanisms underlying CPSP occurrence, based on which different theoretical hypotheses have been proposed.

[High myopia and retinal ultrastructure of albino guinea-pigs].

Objective: To explore the relationship between melanin synthesis and the congenital high myopia of albino guinea-pigs.

Methods: Twelve albino guinea-pigs and 12 pigmented guinea-pigs of 220~250 grams (aged 5~6 weeks) were chosen at random. The eyes were examined with retinoscopy, A-scan ultrasonography and vernier caliper.

[Antisense c-fos oligonucleotides-induced myopia in guinea pigs].

Objective: To characterize the antisense c-fos oligonucleotides that control the expression of immediate-early gene c-fos in retina in order to better understand the mechanism by which antisense c-fos oligonucleotides induced myopia. In this study the signal transduction in the pathway linking visual experience and the regulation of the eye's growth was investigated.

Methods: Thirty-one 3-week guinea pigs were assigned into 3 groups: antisense and sense c-fos oligonucleotides were intravitreally injected every 3 days to the eyes of the experimental guinea pigs at different concentrations; and saline vehicle to control guinea pigs in the same way.

[Apoptosis and c-myc protein expression in the retinal of form-deprivation myopia].

Objective: To study the apoptosis of retina and the expression of c-myc protein in form-deprivation myopia.

Methods: Two-day-old chickens were sutured with right eyelid for 4, 8 and 12 weeks. After measurement of refracation, the eyeballs were observed by light microscope and taken photos.

[Dynamic expression of VIPR2 in form deprivation myopia].

Objective: To investigate the dynamic expression and significance of vasoactive intestinal peptide receptor 2 (VIPR2) on retina-choroid-clera in high myopia.

Methods: Twenty-one yellow chicks of 1 day old were used in the research. The right eyes were the experimental group, covered continuously for 1 week, 2 weeks and 4 weeks respectively.

[Matrix metalloproteinase-2 mRNA expression in the posterior sclera of chick form-deprivation myopia].

Objective: To investigate the dynamic changes of matrix metalloproteinase-2 (MMP-2) mRNA expression in the posterior sclera of chick form-deprivation myopia (FDM) and its possible molecular mechanism.

Methods: Fifty white 1-day-old leghorn chicks were divided randomly and equally into 5 groups. The right eye of each chick was covered with a plastic goggle at 4, 7, 14, 21, and 30 postborn days respectively to induce FDM, and the left eye served as a self-control.

[Dynamic changes of MMP-2 activity in the posterior sclera of chicks with form-deprivation myopia].

Objective: To investigate the effect of form-deprivation on level of gelatinase in the posterior sclera in chicks.

Methods: Fifty 1-day-old chicks were monocularly deprived to establish the animal model of form-deprivation myopia (FDM). According to the duration of form-deprivation the experimental chicks were divided randomly and equivalently into 5 groups, which were deprived for 3, 7, 14, 21 and 30 days respectively.

[The treatment of retinal apoptosis by Caspase 3 inhibitor Ac-DEVD-CHO in experimental myopia].

Objective: To investigate the mechanism of retinal apoptosis in chick experimental myopia and the therapy of Caspase 3 inhibitor Ac-DEVD-CHO.

Methods: Chick myopia was induced by lid-suture. After Ac-DEVD-CHO had been injected into vitreous, myopia was confirmed by optometry.