Publications by authors named "Xin-ping Fu"
Article Synopsis
- The study aimed to evaluate the effectiveness of physical therapy on patients with somatosensory tinnitus (ST) and its impact on various clinical assessments before treatment.
- A total of 43 patients were divided into two groups: an immediate-start group and a delayed-start group, with all receiving therapy for one week, after which improvements in pain and tinnitus-related scores were noted in the immediate-start group.
- Results showed significant positive correlations between improvements and pre-treatment scores of physical symptoms, suggesting that physical therapy can effectively alleviate tinnitus symptoms and enhance quality of life for ST patients, especially those with distinct somatic issues.
Anti-tumor effects of gene therapy with GALV membrane fusion glycoprotein in lung adenocarcinoma.
Cell Biochem Biophys
July 2014
This study examined the efficacy of gene therapy of lung adenocarcinoma using specifically controlled type I herpes simplex virus recombinant vector expressing Gibbon ape leukemia virus membrane fusion glycoprotein gene (GALV.fus). Recombinant HSV-I plasmid carrying target transgene was constructed, and recombinant viral vector was generated in Vero cells using Lipofectamine transfection.
View Article and Find Full Text PDFGene therapy of lung adenocarcinoma using herpes virus expressing a fusogenic membrane glycoprotein.
Cell Biochem Biophys
July 2014
The aim of this study is to observe the in vitro-targeted destruction of lung adenocarcinoma using recombinant Type I herpes simplex virus (HSV-I)-mediated gibbon ape leukemia virus envelope glycoprotein (GALV.fus), controlled by UL38 promoter and cytomegalovirus promoter (CMVP). A recombinant HSV-I plasmid encoding the GALV.
View Article and Find Full Text PDF[The construction of recombinant type I herpes simplex virus carrying GALV.fus gene and its antitumor effect in nude mice].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2011
Article Synopsis
- The study aimed to evaluate the effectiveness of a genetically modified herpes simplex virus (HSV-I) with the Gibbon ape leukemia virus glycoprotein gene in treating lung adenocarcinoma both in cell cultures and live mice models.
- Researchers created three recombinant virus variants (Synco-2, Synco-1, and Baco-1), which were tested on lung cancer cell lines and xenografts, with a control group for comparison.
- Results indicated that Synco-2 and Synco-1 had significantly better tumor-killing effects compared to Baco-1, leading to notable reductions in tumor size and weight in treated mice.
Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. It exists in two isoforms: the full-length STAT3 alpha and the truncated STAT3 beta, generally thought to act as a dominant negative factor. To assess their relative functions, we ablated the expression of either isoform by gene targeting.
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