Spatiotemporal Dynamics of Pro-Inflammatory Mediator Expression in During Ichthyophthiriasis: A 40-Day Longitudinal Study of , , and .

Interleukin-1β (IL-1β), interleukin-6 (IL-6), and serum amyloid A (SAA) are key pro-inflammatory mediators in the regulation of immune responses. The hypothesis posits that their expression varies with the progression of (Ich) infection and may serve as predictors of disease outcome. To elucidate their spatiotemporal dynamics, the full-length CDS of , , and in were cloned, and then their mRNA levels were tracked from infection onset (day 0) to resolution (day 40) or mortality in seven tissues.