Publications by authors named "Xiao-Jiong Peng"
Eur J Med Chem
December 2024
Article Synopsis
- Polymyxins are critical for treating multidrug-resistant gram-negative bacteria, but their use is limited by kidney toxicity, prompting the need for a safer derivative.
- Researchers synthesized 25 polymyxin derivatives, focusing on modifying hydrophobicity and positive charge, ultimately identifying compound 12 with enhanced antibacterial efficacy and reduced nephrotoxicity.
- Compound 12 not only maintained strong activity against both sensitive and resistant bacteria but also improved treatment outcomes when combined with rifampicin, disrupting bacterial cell membranes effectively.
