Publications by authors named "Xiao-Fei Bai"
LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis.
Biochim Biophys Acta Mol Basis Dis
December 2024
Article Synopsis
- Increasing evidence suggests that neuroinflammation plays a role in the progression of Parkinson's disease (PD), with long noncoding RNAs (lncRNAs) significantly impacting inflammatory processes in various diseases.
- The study focused on lncRNA KCNQ1OT1, finding that its knockdown reduced microglial NLRP3 inflammasome activation and decreased dopaminergic neuronal loss in PD model mice.
- KCNQ1OT1 functions by binding with miR-186 to promote inflammasome activation and inhibit its silencing, revealing a new regulatory network that could inform future treatments for Parkinson's disease.
Increased cGAS/STING signaling components in patients with Mooren's ulcer.
Int J Ophthalmol
November 2021
Article Synopsis
- The study aimed to investigate the role of cGAS/STING signaling components in Mooren's ulcer (MU) by comparing tissue samples from MU patients and healthy controls.
- Researchers utilized various methods, including immunohistochemistry and PCR, to measure the expression levels of specific proteins and genes related to the cGAS/STING pathway in the samples.
- Results revealed significantly higher levels of cGAS and STING proteins in MU tissues, along with increased production of interferon-β and interferon-stimulated genes, suggesting that this signaling pathway may influence the progression of MU.
Recombinant human erythropoietin for treating severe traumatic brain injury.
Medicine (Baltimore)
January 2018
Background: This study aimed to explore the efficacy and safety of recombinant human erythropoietin (RHE) for the treatment of severe traumatic brain injury (STBI).
Methods: One hundred and twenty eligible patients with STBI were randomly divided into an intervention group or a control group equally. Patients in the intervention group received RHE.
[Morphology and Spectral Properties Study of LaCeF3:Tb Microcrystalline].
Guang Pu Xue Yu Guang Pu Fen Xi
December 2015
LaCeF3:Tb microcrystalline was synthesized by microemulsion method, oleic acid-assisted solvothermal method, ultrasonic-assisted solvothermal method separately. LaCeF₃:Tb microcrystalline synthesized by ultrasonic-assisted solvothermal method is rarely reported. Using X-ray diffraction (XRD), scanning electron microscope (SEM), fluorescence spectroscopy (PL) method such as the crystal phase, morphology and luminescence properties of the samples have been characterized.
View Article and Find Full Text PDFA new emerging flavivirus caused severe egg-drop in poultry and spread quickly across most duck-producing regions of China in 2010. Complete genome sequencing indicated that the virus genome is 10,989 nucleotides in length and possesses typical flavivirus genome organization, 5' untranslated region (UTR)-Cv-Ci-prM-M-E-NS1-NS2A-NS2B-NS3-NS4A-2K-NS4B-NS5-3'-UTR. The long open reading frame (ORF) encodes 3,425 amino acids (95-10,372 nt).
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