Nomogram for predicting the postoperative outcomes in cervical spondylotic myelopathy based on apparent diffusion coefficient.

Purpose: To development a nomogram based on clinical features and apparent diffusion coefficient (ADC) of the cervical spinal cord in surgical prognosis in patients with cervical spondylotic myelopathy (CSM).

Methods: Patients with CSM who underwent decompression surgery between March and September 2023 were enrolled. Patients underwent conventional cervical spine MRI and sagittal position ZOOM-DWI before surgery.

Bone marrow stromal cell-derived exosome combinate with fibrin on tantalum coating titanium implant accelerates osseointegration.

This study aims to present a sustainably releasing system of exosomes-fibrin combinate loaded on tantalum-coating titanium implants. We hope to investigate potential effects of the system on osseointegration between tantalum coating titanium implants and its surrounding bone tissue. Exosomes derived from rabbit bone marrow stromal cells (rBMSCs) and fibrin were deposited onto the micro-nanostructure tantalum coating surface (Ta + exo + FI) and compared to control groups, including tantalum coating (Ta), tantalum coating loaded exosomes (Ta + exo) and tantalum coating loaded fibrin (Ta + FI).